Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021, 165(4):360-366 | DOI: 10.5507/bp.2021.049

Methods for neovagina creation in women with Mayer-Rokitansky-Küster-Hauser syndrome for subsequent uterus transplantation

Roman Chmel Jra, b, Zlatko Pastora, Marta Novackovaa, Nikoleta Chubanovovaa, Roman Chmela
a Department of Obstetrics and Gynecology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
b Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

Mayer-Rokitansky-Küster-Hauser syndrome is a rare female congenital anomaly that presents with an inability to have coital sexual intercourse and absolute uterine factor infertility. Both surgical and nonsurgical approaches have been described for the treatment of vaginal agenesis to allow satisfactory coitus. Transplantation of the uterus has the challenge of achieving pregnancy and delivery of her own genetic and biological children in a woman without a natural uterus. Women of reproductive age with a congenital form of absolute uterine factor infertility are considered appropriate recipients of a uterus in the experimental phase of uterus transplantation trials. A neovagina in the normal anatomic position covered by natural non-keratinized mucosa is one of the main assumptions for surgical and reproductive success in transplant recipients. More than 70 uterine transplants have been performed to date, and more than 25 childbirths have been achieved by several research centers in the recipients of a uterus with uterine agenesis. In women with Mayer-Rokitansky-Küster-Hauser syndrome, skin-graft neovagina, Vecchietti's vaginoplasty, and self-dilation using Frank's and Ingram's methods are appropriate techniques to create a neovagina if transplantation of the uterus is intended in the future.

Keywords: absolute uterine factor infertility, dilation, Mayer-Rokitansky-Küster-Hauser syndrome, neovagina, uterus transplantation, Vecchietti's method

Received: April 25, 2021; Revised: May 23, 2021; Accepted: July 14, 2021; Prepublished online: August 24, 2021; Published: November 23, 2021  Show citation

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Chmel, R., Pastor, Z., Novackova, M., Chubanovova, N., & Chmel, R. (2021). Methods for neovagina creation in women with Mayer-Rokitansky-Küster-Hauser syndrome for subsequent uterus transplantation. Biomedical papers, 165(4), 360-366. doi: 10.5507/bp.2021.049
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