Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(3):378-381 | DOI: 10.5507/bp.2014.030

Superparamagnetic iron oxide-enhanced magnetic resonance for imaging cardiac inflammation. A minireview

Helena Podrouzkovaa,c, Vera Feitovab,c, Roman Panovskya,c, Jaroslav Meluzina,c, Marek Orbanc
a Department of Cardiovascular Diseases, ICRC, St. Anne's University Hospital in Brno, Czech Republic
b Department of Imaging Methods, ICRC, St. Anne's University Hospital in Brno
c ICRC, St. Anne's University Hospital in Brno

Background: Advances in nanotechnology have lead to the development of a novel contrast media for Magnetic Resonance Imaging (MRI) - the superparamagnetic iron oxide nanoparticle (SPIO). SPIO nanoparticles are used to image inflammation on the cellular level in various settings.

This review covers the physicochemical characteristics of SPIO particles as well as relevant animal and clinical studies and discusses the potential of SPIO particles to image cardiac inflammation including cardiac graft rejection.

Methods: We searched the scientific biomedical databases Medline/PubMed, BioMedCentral, Google Scholar, Ovid and, ProQuest from to 2000 to 2013 for publications relevant to the topic.

Conclusions: SPIO nanoparticles due to their unique properties could become a useful tool in imaging cardiac inflammation. However, the task is to find a suitable particle size and coating with corresponding pharmacokinetics, establish the right dose and MRI scan timing for individual applications.

Keywords: magnetic resonance imaging, inflammation, superparamagnetic iron oxide

Received: October 11, 2013; Accepted: May 29, 2014; Prepublished online: June 19, 2014; Published: September 30, 2015  Show citation

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Podrouzkova, H., Feitova, V., Panovsky, R., Meluzin, J., & Orban, M. (2015). Superparamagnetic iron oxide-enhanced magnetic resonance for imaging cardiac inflammation. A minireview. Biomedical papers, 159(3), 378-381. doi: 10.5507/bp.2014.030
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