Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(3):433-437 | DOI: 10.5507/bp.2012.091

Unusual recurrent rectal carcinoma: A cancer field theory viewpoint

Kamil Vyslouzil^a, Svetlana Brychtova^b, Pavel Zboril^a, Pavel Skalicky^a, Katherine Vomackova^a, Michala Bezdekova^b, Tomas Brychta^c

^a Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic

^b Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc

^c Department of Recreology, Faculty of Physical Culture, Palacky University Olomouc

Aim: The rate of rectal cancer locoregional recurrence following radical surgery varies from 4% to 33%. Though the causes are unclear, likely factors include microscopic tumor residues in the lymphatics, positive resection margins and exfoliation of tumor cells and their subsequent intraluminar spread during operation. Other significant factors include type and technique of surgical procedure. Recently, it has been demonstrated that local recurrence may also be associated with the biological behaviour of the tumor and/or with the composition of the cellular microenvironment which creates optimal conditions for the growth and spread of tumor cells.

Case report: The presented case here is interesting because the tumour recurred early following a curative surgical procedure with negative resection margins, without positive lymph nodes, without infiltration of the pelvic wall and without distant metastases.

Conclusion: In patients with a determined risk of genetically altered tumor field encompassing epithelial or stromal changes, a different treatment strategy, including gene therapy, anti-inflammatory or anti-angiogenic therapy should be chosen to minimize increased tumor risk.

Keywords: rectal cancer, recurrence, cellular microenvironment

Received: February 16, 2012; Prepublished online: November 2, 2012; Published: September 30, 2014  Show citation