Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013, 157(4):325-330 | DOI: 10.5507/bp.2012.101

Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients

Ondrej Ludkaa,c, Jindrich Spinara,c, Josef Tomandlb, Tomas Konecnyc,d
a Internal Cardiology Department, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
b Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno
c International Clinical Research Center, Brno
d Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA

Background: Plasma N-terminal fragment of pro brain natriuretic peptide (NT-proBNP) concentration is elevated in cardiovascular diseases such as congestive heart failure, where increased levels of NT-proBNP indicate cardiac dysfunction, hypervolemia, and higher risk of hospitalization and death. These associations apply also to patients with severe impairment of kidney function. Little is known about diferences in plasma level of NT-proBNP in patients receiving hemodialysis (HD) versus those receiving continuous ambulatory peritoneal dialysis (CAPD).

Aim: To evaluate differences in plasma NT-proBNP concentration between HD and CAPD patients.

Methods: Plasma NT-proBNP concentration was prospectively measured in consecutive patients receiving either HD or CAPD at our hospital center. All other standard clinical parameters were recorded. The correlation between plasma NT-proBNP concentration and the type of dialysis was then examined.

Results: We studied 99 consecutive patients on HD (age 62 ± 15 years, 66% male) and 18 consecutive patients on CAPD (age 56 ± 18 years, 67% male). Both groups had similar baseline characteristics including duration of dialysis, left ventricular function and mass, and cardiothoracic ratio. Significantly more patients on HD had abnormal NT-proBNP levels compared to patients on CAPD (97% vs 44%; P

Keywords: hemodialysis, continuous ambulatory peritoneal dialysis, NT-proBNP, ejection fraction

Received: June 8, 2012; Accepted: October 23, 2012; Prepublished online: November 13, 2012; Published: December 12, 2013  Show citation

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Ludka, O., Spinar, J., Tomandl, J., & Konecny, T. (2013). Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients. Biomedical papers157(4), 325-330. doi: 10.5507/bp.2012.101
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References

  1. Maisel A. The coming of age of natriuretic peptides: the emperor does have clothes! J Am Coll Cardiol. 2006;47:61-4. Go to original source... Go to PubMed...
  2. Hammerer-Lercher A, Puschendorf B, Mair J. Cardiac natriuretic peptides: new laboratory parameters in heart failure patients. Clin Lab 2001;47:265-77. Go to PubMed...
  3. Gegenhuber A, Mueller T, Firlinger F, Lenz K, Poelz W, Haltmayer M. Time course of B-type natriuretic peptide (BNP) and N-terminal proBNP changes in patients with decompensated heart failure. Clin Chem 2004;50:454-6. Go to original source... Go to PubMed...
  4. Yamamoto K, Burnett JC Jr, Bermudez EA, Jougasaki M, Bailey KR, Redfield MM. Clinical criteria and biochemical markers for the detection of systolic dysfunction. J Card Fail 2000;6:194-200. Go to original source... Go to PubMed...
  5. Maisel AS, Koon J, Krishnaswamy P, Kazenegra R, Clopton P, Gardetto N, Morrisey R, Garcia A, Chiu A, De MA. Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am Heart J 2001;141:367-74. Go to original source... Go to PubMed...
  6. Vasan RS, Benjamin EJ, Larson MG, Leip EP, Wang TJ, Wilson PW, Levy D. Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: The Framingham heart study. JAMA 2002;288:1252-9. Go to original source... Go to PubMed...
  7. Tateishi J, Masutani M, Ohyanagi M, Iwasaki T. Transient increase in plasma brain (B-type) natriuretic peptide after percutaneous transluminal coronary angioplasty. Clin Cardiol 2000;23:776-80. Go to original source... Go to PubMed...
  8. Kikuta K, Yasue H, Yoshimura M. Increased plasma levels of B-type natriuretic peptide in patients with unstable angina. Am Heart J 1996;132:101-7. Go to original source... Go to PubMed...
  9. Goetze JP, Christoffersen C, Perko M, Arendrup H, Rehfeld JF, Kastrup J, Nielsen LB. Increased cardiac BNP expression associated with myocardial ischemia. FASEB J 2003;17:1105-7. Go to original source... Go to PubMed...
  10. Gardner RS, Ozalp F, Murday AJ, Robb SD, McDonagh TA. N-terminal pro-brain Natriuretic Peptide a New Gold Standard in Predicting Mortality in Patiens with Advanced Heart Failure. Eur Heart J 2003;24:1735-43. Go to original source... Go to PubMed...
  11. Nielsen LS, Svanegaard J, Klitgaard NA, Egeblad H. N-terminal pro-brain Natriuretic Peptide for discriminating between Cardiac and Non-cardiac Dyspnoea. Euro. J. Heart Failure 2004;6:63-70. Go to original source... Go to PubMed...
  12. Tsumamoto T, Wada A, Maeda K. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patiens with chronic symptomatic left ventricular dysfunction. Circulation 1997;96:509-16. Go to original source... Go to PubMed...
  13. Januzzi JL Jr, Camargo CA, Anwaruddin S. The N-terminal pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 2005;95:48-54. Go to original source... Go to PubMed...
  14. Kazanegra R, Cheng V, Garcia A, Krishnaswamy P, Gardetto N, Clopton P, Maisel A. A rapid test for B-type natriuretic peptide correlates with falling wedge pressures in patients treated for decompensated heart failure: A pilot study. J Card Fail 2001;7:21-9. Go to original source... Go to PubMed...
  15. Rahman M, Dixit A, Donley V, Gupta S, Hanslik T, Lacson E, Ogundipe A, Weigel K, Smith KC. Factors associated with inadequate blood pressure control in hypertensive hemodialysis patients. Am J Kidney Dis 1999;33:498-506. Go to original source... Go to PubMed...
  16. Gunal AI, Duman S, Ozkahya M, Toz H, Asci G, Akcicek F, Basci A. Strict volume control normalizes hypertension in peritoneal dialysis patients. Am J Kidney Dis 2001;37:588-93. Go to original source... Go to PubMed...
  17. Koc M, Toprak A, Tezcan H, Bihorac A, Akoglu E, Ozener IC. Uncontrolled hypertension due to volume overload contributes to higher left ventricular mass index in CAPD patients. Nephrol Dial Transplant 2002;17:1661-6. Go to original source... Go to PubMed...
  18. Konings CJ, Kooman JP, Schonck M, Dammers R, Cheriex E, Palmans Meulemans AP, Hoeks AP, van Kreel B, Gladziwa U, van der Sande FM, Leunissen KM. Fluid status, blood pressure, and cardiovascular abnormalities in patients on peritoneal dialysis. Perit Dial Int 2002;22:477-87. Go to original source... Go to PubMed...
  19. Foley RN, Parfrey PS, Sarnak MJ. Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 1998;9:S16-S23. Go to original source...
  20. Ludka O, Spinar J, Vitovcova L, Sobotova D, Spinarova L, Pozdisek Z, Musil V, Vitovec J, Tomandl J. Variability of plasmatic levels of big endothelin and NT-proBNP in patients with heart failure in a chronic haemodialysis programme. Vnitr Lek 2007;53(11):1177-81. Go to PubMed...
  21. Lang CC, Choy AM, Henderson IS. Effect of haemodialysis on plasma levels of brain natriuretic peptide in patients with chronic renal failure. Clin Sci (Lond) 1992;82:127-31. Go to original source... Go to PubMed...
  22. Horl WH. Natriuretic peptides in acute and chronic kidney disease and during renal replacement therapy. J Investig Med 2005;53:366-70. Go to original source... Go to PubMed...
  23. Stejfa M a kol. Kardiologie. Grada; 1998. P. 492.
  24. Khalifeh N, Haider D, Horl WH. Natriuretic Peptides in Chronic Kidney Disease and During Renal Replacement Therapy: An Update. Journal of Investigative Medicine 2009;57(1):33-9. Go to original source... Go to PubMed...
  25. Dhar S, Pressman GS, Subramanian S, Kaul S, Gollamudi S, Bloom EF, Figueredo VM. Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence. Postgrad Med J 2009;85:299-302. Go to original source... Go to PubMed...
  26. Wahl HG, Graf S, Renz H, Fassbinder W. Elimination of the Cardiac Natriuretic Peptides B-Type Natriuretic Peptide (BNP) and N-Terminal proBNP by Hemodialysis. Clinical Chemistry 2004;50(6):1071-3. Go to original source... Go to PubMed...
  27. Nakatani T, Naganuma T, Mazura C, Uchida J, Sugimura T, Sugimura K. Significance of brain natriuretic peptides in patients on continuous ambulatory peritoneal dialysis. International Journal of Molecular Medicine 2002;10:457-61. Go to original source... Go to PubMed...
  28. Al-Hweish A, Sultan SS, Mogazi K, Elsammak MY. Plasma myeloperoxidase, NT-proBNP, and troponin-I in patients on CAPD compared with those on regular hemodialysis. Hemodial Int 2010;14(3):308-15. Go to original source... Go to PubMed...
  29. Sanjuan R, Oliva SM, Blasco ML, Puchades M, Torregrosa I, Ramon RG, Carrasco AM. Plasma Brain Natriuretic Peptide Levels in Cardiac Function Assessment in Chronic Dialysis Patients. Cardiorenal Med 2011;1(3):147-55. Go to original source... Go to PubMed...
  30. Bavbek N, Akay H, Altay M, Uz E, Turgut F, Uyar ME, Karanfil A, Selcoki Y, Akcay A, Duranay M. Serum BNP concentration and left ventricular mass in CAPD and automated peritoneal dialysis patients. Perit Dial Int 2007;27(6):663-8. Go to original source... Go to PubMed...