Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012, 156(3):218-222 | DOI: 10.5507/bp.2012.065

Comparison of immunological properties of various bioactive combinations

Vaclav Vetvicka, Jana Vetvickova
Department of Pathology, University of Louisville, Louisville, KY, USA

Background: Lately, more and more preparation of various cocktails or mixtures of bioactive modulators have been introduced. Their true activity is, however, rarely tested.

Aim: To compare six commercially available, glucan-based immunostimulators.

Methods: Immunological effects of tested combinations were measured by evaluation of phagocytosis of synthetic particles by peripheral blood neutrophils, production of IL-2 by mouse splenocytes, production of superoxide anion and nitrite oxide, antibody response to imunization with ovalbumin, and NK cell activity.

Results: Our results showed that with the exception of the highest doses (phagocytosis) and superoxide anion and nitrite oxide production, only RVB 300 showed significant immunostimulative activity.

Conclusion: Based on our results, we can conclude that most of the tested natural immunomodulators have limited, if any, biological effects. Only RVB 300 significantly stimulated all six tested immunological reactions.

Keywords: glucan, phagocytosis, IL-2, NK cells, antibodies

Received: April 20, 2012; Accepted: June 18, 2012; Prepublished online: September 21, 2012; Published: September 1, 2012  Show citation

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Vetvicka, V., & Vetvickova, J. (2012). Comparison of immunological properties of various bioactive combinations. Biomedical papers, 156(3), 218-222. doi: 10.5507/bp.2012.065
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