Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011, 155(4):397-401 | DOI: 10.5507/bp.2011.062

AN UNUSUAL CASE OF MULTI-RECURRENT HERPES ZOSTER (HZ): A CASE REPORT

Vanda Bostikovaa, Miloslav Salavecb, Jan Smetanaa, Roman Chlibeka, Pavel Kosinac, Petr Prasilc, Stanislav Plisekc, Miroslav Splinoa, Pavel Bostika,c
a Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
b Department of Dermatology and cDepartment of Infectious Diseases, Charles University Medical School and University
c Hospital, Hradec Kralove

Aims: We report a case of multi-recurrent herpes zoster in a 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over the years 2009 - 2011.

Methods: Specific PCR methods targeting single nucleotide polymorphisms (SNPs) in open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons in ORF 22 and/or ORF 21/ORF 50. Additional genotyping in ORF 1, 6, 9 and 28 was subsequently performed due to the unusual results.

Results: Three sets of clinical specimens from one patient (from hospital visits 2, 3 and 4) were analyzed and the presence of an unusual wild-type strain of VZV was discovered. The VZV strain isolated from the lesions bears a combination of markers characteristic both for Mosaic 2 (M2) and European 1 (E1) wild-type VZV strains.

Conclusion: This is the first report of atypical wild-type VZV strain circulating currently in Czech Republic.

Keywords: Herpes zoster, Varicella-zoster virus, Wild-type strain, Czech Republic

Received: July 13, 2011; Accepted: November 15, 2011; Prepublished online: December 20, 2011; Published: December 1, 2011  Show citation

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Bostikova, V., Salavec, M., Smetana, J., Chlibek, R., Kosina, P., Prasil, P., ... Bostik, P. (2011). AN UNUSUAL CASE OF MULTI-RECURRENT HERPES ZOSTER (HZ): A CASE REPORT. Biomedical papers, 155(4), 397-401. doi: 10.5507/bp.2011.062
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    References

    1. Arvin AM. Varicella-zoster virus: overview and clinical manifestations. Semin Dermatol 1996;15:4-7. Go to PubMed...
    2. Bostikova V, Salavec M, Splino M, Chlibek R, Smetana J, Vackova M, Hanovcova I, Bostik P. The role of sequence analysis of wildtype varicella-zoster virus in epidemiological and evolutionary characterization of VZV:focus on epidemiologic situation in Czech Republic. Vakcinologie 2010;2(4):55-9 (in Czech).
    3. Smetana J, Salavec M, Bostikova V, Chlibek R, Bostik P, Hanovcova I, Vackova M, Matulkova P, Splino M. Herpes zoster in Czech Republic epidemiology and clinical symtoms. EMI 2010;3:138-46 (in Czech).
    4. Sutradhar SC, Wang WW, Schlienger K, Stek JE,Xu J,., Chan IS, Silber JL. Comparison of the levels of immunogenicity and safety of Zostavax in adults 50 to 59 years old and in adults 60 years old or older. Clin Vaccine Immunol 2009;16(5):646-52. Go to original source... Go to PubMed...
    5. Sampathkumar P, Drage LA, Martin DP. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc 2009;84(3):274-80. Go to original source... Go to PubMed...
    6. Larussa PS, Gershon AA. Biologic and geographic differences between vaccine and clinical varicella-zoster virus isolates. Arch Virol Suppl 2001;41-8. Go to original source...
    7. Loparev VN, Gonzalez M, Deleon-Carnes M, Tipples G, Fickenscher E., Torfason E, Schmid DS. Global identification of three major genotypes of varicella-zoster virus: longitudinal clustering and strategies for genotyping. J Virol 2004;78;8349-58. Go to original source... Go to PubMed...
    8. Loparev VN, Rubtcova EN, Bostik V, Govil D, Birch CJ, Druce JD, Schmid DS, Croxson MC. Identification of five major and two minor genotypes of varicella-zoster virus strains: a practical twoamplicon approach used to genotype clinical isolates in Australia and New Zealand. J Virol 2007;81(23):12758-65. Go to original source... Go to PubMed...
    9. Loparev VN, Rubtcova EN, Bostik V, Tzaneva V, Sauerbrei A, Robo A, Sattler-Dorbacher E, Hanovcova I, Stepanova V, Eremin V, Koskiniemi M, Vankova OE, Schmid SD.Distribution of varicellazoster virus (VZV) wild type genotypes in northern and southern Europe: evidence for high conservation of circulating genotypes. Virology 2009;383(2):216-25. Go to original source... Go to PubMed...
    10. LaRussa P, Lungu O, Hardy I, Gershon A, Steinberg SP, Silverstein S. Restriction fragment length polymorphism of polymerase chain reaction products from vaccine and wild-type varicella-zoster virus isolates. J Virol 1992;66:1016-20. Go to original source...
    11. Loparev VN, McCaustland BP, Holloway PR, Takayama M, Schmid DS. Rapid genotyping of varicella-zoster virus vaccine and wildtype strains with fluorophore-labeled hybridization probes. J Clin Microbiol 2000;38:4315-19. Go to original source... Go to PubMed...
    12. Loparev VN, Rubtcova E, Seward J, Schmid DS, Levin M. DNA Sequence Variability in Isolates Recovered from Patients with Postvaccination Rash or Herpes Zoster Caused by Oka Varicella Vaccine. J Infect Dis 2007;195:802-10. Go to original source... Go to PubMed...

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