Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010, 154(1):9-12 | DOI: 10.5507/bp.2010.004

HUMAN PAPILLOMAVIRUS IN THE ETIOLOGY OF HEAD AND NECK CARCINOMAS

Petr Michla, Jindrich Pazderaa, Martin Prochazkab, Richard Pinka, Tatana Stosovac
a Department of Oral and Maxillofacial Surgery, University Hospital Olomouc, I. P. Pavlova 6, Olomouc 77900, Czech Republic
b Department of Obstetrics and Gynecology, University Hospital Olomouc, I. P. Pavlova 6, Olomouc 77900
c Department of Microbiology, Faculty of Medicine and Dentistry, Olomouc, Hnevotinska 3, Olomouc 77900

Background: For more than 20 years, infection with the human papillomavirus (HPV) has been of a matter of interest not only to gynecologists but also to maxillofacial surgeons and othorhinolaryngologists. HPV is generally known to be involved in cervical cancer. Recently, there are many clinical studies pointed out the potentially dangerous connection between HPV infection and head and neck carcinomas (HNC). HPV infection was identified as a possible etiological factor in 15-30% of HNC.

Methods: Aim of this article is to summarize the recent knowledge about the HPV infection with regards to etiology of head and neck cancer.

Results: It has been proven that HPV infection is related to development of head and neck cancer and that the sexual behavior has played an important role in the viral transmission. HNC of viral etiology have been observed mostly in younger people; their curability is difficult and prognosis serious.

Conclusion: Beside the well known correlation between developing of new head and neck cancer and bad habits (smoking, alcohol abuse, poor oral hygiene etc.) we should take into consideration the sexual promiscuity and alternative sexual practices. Vaccination against cervical cancer, recommended to young women, should be extended to their male partners to prevent the virus transmission and decrease the HNC incidence.

Keywords: HPV infection, Head and neck carcinomas, Vaccination

Received: May 14, 2009; Accepted: February 2, 2010; Published: March 1, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Michl, P., Pazdera, J., Prochazka, M., Pink, R., & Stosova, T. (2010). HUMAN PAPILLOMAVIRUS IN THE ETIOLOGY OF HEAD AND NECK CARCINOMAS. Biomedical papers, 154(1), 9-12. doi: 10.5507/bp.2010.004
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Kupferman ME, Myers JN: Molecular biology of oral cavity squamous cell carcinoma. Otolaryngol Clin N Am 2006; 39:229247. Go to original source... Go to PubMed...
    2. Kufe DW, Holland JF, Frei E. American cancer society, Cancer medicine, 6th edition. Lewiston: BC Decker 2003; 6:2.
    3. Ries LAG, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review. National Cancer Institute Bethesda 2006. 19752004.
    4. Shiboski CH, Schmidt BL, Jordan RC, et al. Tongue and tonsil carcinoma: increasing trends in the US population ages 2044 years. Cancer 2005; 103:18431849. Go to original source... Go to PubMed...
    5. Canto MT, Devesa SS. Oral cavity and pharynx cancer incidences rates in the United States. 19751998. Oral Oncol 2002; 38:610 617. Go to original source... Go to PubMed...
    6. Frisch M, Hjalgrim H, Jaeger AB, et al. Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control 2000; 11:489495. Go to original source... Go to PubMed...
    7. Gillison ML, Koch WM, Capone RB. Evidence for a casual association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92:709720. Go to original source... Go to PubMed...
    8. Mork L, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001; 344:11251131. Go to original source... Go to PubMed...
    9. Niedobitek G, Pitteroff S, Herbst S, et al. Detection of type 16 DNA in carcinomas of the palatine tonsil. J Clin Pathol 1990; 43:918921. Go to original source... Go to PubMed...
    10. Adams V, Schmid S, Zariwala M, et al. Prevalence of human papillomavirus DNA in head and neck cancer carrying wild type or mutant p53 tumor suppressor genes. Anticancer Res 1999; 19:16.
    11. Venuti A, Manni V, Morello R, et al. Physical state and expression of human papillomavirus in laryngeal carcinoma and surrounding normal mucosa. J Med Virol 2000; 60:396402. Go to original source... Go to PubMed...
    12. Zang ZY, Sdek P, Cao J, et al. Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa. Int J Oral Maxillofac Surg 2004; 33:7174. Go to original source... Go to PubMed...
    13. Schlecht NF, Burk RD, Adrien L, Dunne A, Kawachi N, Sarta C, Chen Q, Brandwein-Gensler M, Prystowsky MB, Childs G, Smith RV, Belbin TJ. Gene expression profiles in HPV-infected head and neck cancer. J Pathol 2007; 213:283293. Go to original source... Go to PubMed...
    14. Zhao M, Rosenbaum E, Carvalho AL, Koch W, Jiang WW, Sidransky D, Califano J. Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int J Cancer 2005; 117: 605610. Go to original source... Go to PubMed...
    15. Hannahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100(1):5770. Go to original source... Go to PubMed...
    16. Fakhry C, Westra W, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in prospective clinical trial. J Natl Cancer Inst 2008; 100:261269. Go to original source... Go to PubMed...
    17. Gillison ML, D'Souza G, Westra W, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008; 100:407420. Go to original source...
    18. Herrero R, Castellsague X, Pawlita M, et al. Human papillomavirus and oral cancer: the International Agency for Research on cancer multicenter study. J Natl Cancer Inst 2003; 95:17721783. Go to original source... Go to PubMed...
    19. Hansson BG, Rosenquist K, Antonsson A, et al. Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol 2005; 125:13371344. Go to original source... Go to PubMed...
    20. Smith EM, Ritchie JM, Summersgill KF, et al. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 2004; 108:766772. Go to original source... Go to PubMed...
    21. Badaracco G, Rizzo C, Mafera B, Pichi B, Giannarelli D, Rahimi SS, Vigili MG, Venuti A. Molecular analyses and prognostic relevance of HPV in head and neck tumors:. Oncology Reports 2007; 17:931939. Go to original source...
    22. Vidal L, Gillison ML. Human Papillomavirus in HNSCC: Recognition of a Distinct Disease Type. Hematol Oncol Clin N Am 2008; 22:11251142. Go to original source... Go to PubMed...
    23. Stubenrauch F, Laimins LA. Human Papillomavirus life cycle: active and latent phases. Semin Cancer Biol 1999; 9:379386. Go to original source... Go to PubMed...
    24. McKaig RG, Baric RS, Olshan AF. Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head and Neck 1998; 20:250265. Go to original source... Go to PubMed...
    25. DSouza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356:19441956. Go to original source... Go to PubMed...
    26. Mellin H, Friesland S, Lewensohn R, et al. Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int J Cancer 2000; 89:300304. Go to original source... Go to PubMed...
    27. Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM, Mao E-J, Fitzgibbons ED, Huang S, Beckmann AM, McDougall JK, Galloway DA. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 1998; 90:16261636. Go to original source... Go to PubMed...
    28. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kollings J, Jungehuelsing M, Eckel HE, Dienes HP, Pfister HJ, Fuchs PG. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001; 92:287584. Go to original source... Go to PubMed...
    29. Wilczynski S, Lin B, Xie Y, Paz B. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol 1998; 152:14556.
    30. Ragin CCR, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papilomavirus infection: Review and mwta-analysis. Int J Cancer 2007; 121:18131820. Go to original source... Go to PubMed...
    31. Akervall JA, Michalides RJ, Mineta H, Balm A, Borg A, Dictor MR, Jin Y, Loftus B, Mertens F, Wennerberg JP. Amplification of cyclin D1 in squamous cell carcinoma of head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 1997; 79:380389. Go to original source... Go to PubMed...
    32. Rodrigo JP, Garcia LA, Ramos S, Lazo PS, Suarez C. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinoma of the head and neck. Clin Cancer Res 2000; 6:31773182. Go to original source...
    33. Namazie A, Alavi S, Olopade OI, Pauletti G, Aghamohammadi N, Aghamohammadi M, Gornbein JA, Calcaterra TC, Slamon DJ, Wang MB, Srivatsan ES. Cyclin D1 amplification and p16(MTS1/ CDK4I)deletion correlate with poor prognosis in head and neck tumors. Laryngoscope 2002; 112:472481. Go to original source... Go to PubMed...
    34. Fuji M, Ishiguro R, Yamashita T, Tashiro M. Cyclin D1 amplification correlates with early recurrence of squamous cell carcinoma of the tongue. Cancer Lett 2001; 172:187192. Go to original source... Go to PubMed...
    35. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A systematic Review. Cancer Epidemiol Biomarkers Prev 2005; 14(2):467475. Go to original source... Go to PubMed...
    36. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A systematic Review. Cancer Epidemiol Biomarkers Prev 2005; 14(2):467475. Go to original source... Go to PubMed...

    Return to the content