Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007, 151(1):143-146 | DOI: 10.5507/bp.2007.028

LASER DOPPLER FLUXMETRY

Stanislav Sarnik, Ivo Hofirek, Ondrej Sochor
1st Department of Internal Medicine, Cardioangiology, St. Anne's University Hospital Brno

Background: Laser Doppler fl uxmetry (LDF) is an extraordinary sensitive noninvasive method of examination. It can be used for monitoring changes in the cutaneous peripheral microcirculation15. It uses a monochromatic low-energy laser beam. This beam penetrates the tissue and, depending on individual tissue penetration, it is refl ected, recorded by a sensitive sensor and subsequently analyzed using the Doppler. Laser Doppler fl uxmetry detects movement of cells in the peripheral circulation and microcirculation.

Methods: The light from the laser source is delivered via optical fibers to the tissue. In the tissue the light collides with moving blood elements; after a collision, the wave length of the light changes - this phenomenon is called Doppler shift. Our own method of measurement has already been fully developed. We have a group of patients with physiological findings and also groups of patients with vasoneurosis, patients with type 1 diabetes mellitus, vasculitis patients, and other patient groups. We examine the blood fl ow on the dorsal side of fingers or toes. There are many protocols for laser Doppler examination. For all the patient groups we used a protocol evaluating an algorithm, developed in the training department of the Perimed company, using provocation tests for the assessment of the vascular wall function in addition to records at rest. Use of laser Doppler: We have developed a method of use of laser Doppler examination in about 8 years. We have examined several groups of patients. First a patient group with physiological findings was examined, and subsequently groups of patients with vasculitis, vasoneurosis, and a group of patients with type l diabetes mellitus. Recently, monitoring has been performed in patients after cardioversion in chronic atrial fibrillation with sinus rhythm restitution, and also data obtained before and after a varicose vein operation on lower limbs have been compared.

Conclusion: Clear diagnostic criteria for this method do not exist so far. For the time being this is a rather theoretical method that we used even in practice for the above mentioned diseases. The method provides enough data even for more detailed analyses. The information valu of the curve arises after statistical data analysis with the t-test.

Keywords: Laser Doppler fl uxmetry, Perifl ux 5000, Tissue blood supply, Peripheral microcirculation

Received: April 30, 2007; Accepted: June 1, 2007; Published: June 1, 2007  Show citation

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Sarnik, S., Hofirek, I., & Sochor, O. (2007). LASER DOPPLER FLUXMETRY. Biomedical papers, 151(1), 143-146. doi: 10.5507/bp.2007.028
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    References

    1. Mayrovitz H.N.- Groseclose E.E.: Inspiration-induced vascular responses in fi nger dorsum skin. Microvascular Research 2002; 3:2326. Go to original source... Go to PubMed...
    2. Crandall C G, Shibasaki M, Yen T C. Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanism. Journal of Physiology 2002; l:3639. Go to original source... Go to PubMed...
    3. Hofirek I. Vasculitidy, vasculopatie. Kardiologicka revue; Brno 3, p. 1113
    4. Prázný M. Examination of tissue perfusion by laser doppler fl owmetry. Diabetes, metabolismus, endokrinologie 2000; 2:3033.
    5. www.medata.cz. Evaluations
    6. www.perimed.se
    7. Microcirculatory stasis, at the root of venous disease, Phlebo-lymphology, No.5, European Conference on Microcirculation; 1994, Rome, p. 3638
    8. Bornmyr S, Arner M, Svensson H. Laser Doppler imaging of fi nger skin blood fl ow in patients after microvascular repair of the ulnar artery at the wrist Journal of Hand Surgery 1994; 19B(3):295300. Go to original source...
    9. Bornmyr S, Svensson H, Söderström T, Sundkvist G, Wollmer P. Finger skin blood fl ow in response to indirect cooling in normal subjects and in patients before and after sympathectomy Clinical Physiology 1998; 18(2): 103107. Go to original source... Go to PubMed...
    10. Ferrell W R, Sturrock R D, Mallik A K, Abbot N C, Lockhart J C, Edmondson W D. Laser Doppler perfusion imaging of proximal interphalangeal joints in patients with rheumatoid arthritis Clinical and Experimental Rheumatology 1996; 14:649652.
    11. Picart C, Carpentier P H, Brasseur S, Galliard H, Piau J.M. Systemic sclerosis: Blood rheometry and laser Doppler imaging of digital cutaneous microcirculation during local cold exposure Clinical Hemorheology and Microcirculation 1998; 18:4758.
    12. Hofírek I, Sochor O, Olšovský J. Změny periferní mikrocirkulace u diabetiků 1. typu sledované laser dopperem. Vnitřní lékařství 2004; 50(11):836841.
    13. Sarnik S. Poruchy mikrocirkulace u chronicke zilni nedostatecnosti. Kardiologicka revue 2005; 7(3):152155.
    14. Sochor O, Hofirek I. How long change cigarette peripheral vasomotion? Prakticka fl ebologie in print
    15. Sochor O, Hofirek I, Vitovec J. Peripheral microcirculation during the extracorporal circulatoin using frequency analysis of Laser Doppler Fluxmetry. International Angiology 2006; 25(2), suppl 1:182
    16. Hofirek I, Sochor O, Sarnik S. Vliv diabetu na reaktivitu mikrocirkulace u pacientu s vasospastickym onemocnenim a vliv rheologicke terapie. CEVJ (Central European Vascular Journal) Feb 2007; 6(1):13
    17. Sochor O. Smokers and vascular diseases. What should we do with them? CEVJ (Central European Vascular Journal) Feb 2007; 6(1):17.

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