Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(2):363-366 | DOI: 10.5507/bp.2006.056

Lipid metabolism in active Crohn's disease: Pre-results

Vladimir Hrabovskya, Zdenek Zadakb, Vladimir Blahac, Radomir Hysplerc, Alena Tichac, Tomas Karlikd
a Intensive Care Unit, Department of Internal Medicine, Faculty Hospital Ostrava, Czech Republic
b Department of Research and Development, Charles University Prague, Faculty of Medicine Hradec Králové, Czech Republic
c Department of Metabolic Care and Gerontology, Faculty Hospital Hradec Králove, Czech Republic
d Department of Clinical Biochemistry, Faculty Hospital Ostrava, Czech Republic

Background: Crohn's disease (CD) is a chronic relapsing disease. Especially acute period may be associated with metabolic disturbances. Alteration of lipid metabolism has been described in critically ill patients and hypocholesterolemia is associated with poor prognosis. The human organism acquires cholesterol by two principal processes - synthesis de novo, and absorption from the diet. It is possible to assess, using cholesterol synthesis markers (lathosterol) and cholesterol absorption markers (sitosterol, campesterol) the leading form of cholesterol acquisition.

Aim: The aim of this study is assess the association between the lipid profile in plasma and the plasma concentration of sterols in active CD patients and in control subjects.

Method: Routine laboratory tests, CDAI, lipid and non-cholesterol sterols plasma levels were performed on days 3, 14 and 28. The metabolic parameters have been compared with a control cohort of 100 healthy blood donors.

Results: Presently, complete data for 8 patients are available The serum total cholesterol, LDL and HDL cholesterol, and triglyceride concentrations were lower in patients with acute Crohn's disease than in the control group. Moreover lathosterol, campesterol and sitosterol concentrations were lower, whereas squalene concentration was higher than in controls. As mentioned above, complete data are not currently available. Therefore statistical analysis has not been finished.

Conclusion: Our pre-results show substantial abnormalities in the concentrations of plasma lipids and non-cholesterol sterols, which are presented as markers of cholesterol requirement, in patients with acute CD.

Keywords: Keywords: Inflammation, Lipids, Nutrition

Received: October 18, 2006; Accepted: November 11, 2006; Published: December 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hrabovsky, V., Zadak, Z., Blaha, V., Hyspler, R., Ticha, A., & Karlik, T. (2006). Lipid metabolism in active Crohn's disease: Pre-results. Biomedical papers, 150(2), 363-366. doi: 10.5507/bp.2006.056
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Giovannini I, Boldrini G, Chiarla C, Guiliante F, Vellone M, Nuzzo G. Pathophysiologic correlates of hypocholesterolemia in critically ill surgical patients. Int Care Med 1999; 25:74851 Go to original source... Go to PubMed...
    2. Bakalář B, Zadák Z, Pachl J,Hyšpler R,Crhová S. Influence of severe trauma on cholesterol synthesis. Int Care Med 2000; 26, S3:357
    3. Fraunberger P, Nagel D, Walli AK,Seidel D. Serum cholesterol and mortality in patients with multiple organ failure. Crit Care Med 2000; 28:35745 Go to original source... Go to PubMed...
    4. Bakalář B, Zadák Z, Pachl J, Hyšpler R, Crhová Š, Karásek J, Čapek V. Severe hypocholesterolemia is associated with adrenal insufficiency in multiple trauma patients. Int Care Med 2001; 27, Suppl 2:253.
    5. Giovannini I, Chiarla C, Greco F, Boldrini G, Nuzzo G. Characterization of biochemical and clinical correlates of hypocholesterolemia after hepatectomy. Clin Chemistry 2003; 49: 317320 Go to original source... Go to PubMed...
    6. Gordon BR, Parker TS, Levine DM, Saal SD, Wang JCL, Sloan B-J,at al. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill patients. Crit Care Med 2001; 29:15631568 Go to original source... Go to PubMed...
    7. Bonville DA, Parker TS, Levine DM, Gordon BR, Hydo LJ, Eachempati SR, et al. The relationship of hypocholesterolemia to cytokine concentrations and mortality in critically ill patients with systemic inflammatory response syndrome. Surg Infect 2004; 5:3949 Go to original source... Go to PubMed...
    8. Zadák Z, Hyšpler R, Havel E, Bláha V, Sobotka L, Žďánský P, et al. Changes in metabolism of cholesterol and its precursors in critical patients on total parenteral nutrition. Nutrition 2002; 18:214
    9. Tilvis RS, Miettinen TA. Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutrition
    10. Pfohl M, Naoumova RP, Kim KD et al. Use of cholesterol precursors to assess changes in cholesterol synthesis under non.steadystate conditions. Eur J Clin Ivestig 1998; 28:491496. Go to original source... Go to PubMed...
    11. Barton BE. IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation. Immunology research 2001; 23:4158. Go to original source... Go to PubMed...
    12. McLean SJ, Rombeau JL. Cytokines and inflammatory bowel disease: a review. Journal of parenteral and enteral nutrition 1998; 23:2024. Go to original source... Go to PubMed...
    13. Vointk AJ, Echave V, Feller JH, Brown RA, Gurd FN. Experience with elemental diet in the treatment of inflammatory bowel disease. Is this primary therapy? Arc Surg 1973; 107:329333. Go to original source... Go to PubMed...
    14. Greenberg GR, Fleming CR, Jeejeebhoy KN, et al.Controlled trial of bowel rest and nutrition support in the management of Crohns disease. Gut 1998; 29:13091315.
    15. Gassul MA, Fernandez-Baňares F, Cabre E. et al. Fat composition may be a clue to explain the primary therapeutic effect of enteral nutrition in Crohns disease: results of a double blind randomized multicentre European trial. Gut 2002; 51:164168. Go to original source... Go to PubMed...
    16. Miura S, Tsuzuki Y, Hokari R, Ishii H. Modulation of intestinal immune system by dietary fat intake: Relevance to Crohn disease. J Gastroenterol Hepatol 1998; 13:11831190. Go to original source... Go to PubMed...
    17. Bamba T, Shimoyama T,Sasaki M, Tsujikawa T, Fukuda Y, Koganei K, at al. Dietary fat attenuates the benefit of an elemental diet in active Crohns disease: a randomized, controlled trial. Eur J Gastroenterol Hepatol 2003; 15:151157. Go to original source... Go to PubMed...
    18. Belluzi A, Brignota C, Campieri M. et al.: Effect of an entericcoated fish-oil preparation on relapses in Crohns disease. N Eng J Med 1996; 334:15571560. Go to original source... Go to PubMed...
    19. Levy E, Rizwan Y, Thibault L, Lepage G, Brunet S., Bouthillier L, et al. Altered lipid profile, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn disease. Am J Clin Nutr 2000; 71:807815. Go to original source... Go to PubMed...
    20. Geerling BJ, v. Houwelingen AC, Badart-Smook A, Stockbrügger RW, Brummer RJM. The relation between antioxidant status and alterations in fatty acid profile in patients with Crohn disease and controls. Scand J Gastroenterol 1999; 11:11081116. Go to original source... Go to PubMed...
    21. Kuksis A. Plasma non-cholesterol sterols. J Chromatogr 2001; 935:203236. Go to original source... Go to PubMed...

    Return to the content