Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(2):289-292 | DOI: 10.5507/bp.2006.044

PREVALENCE OF INHERITED THROMBOPHILIA IN PATIENTS WITH SEVERE OVARIAN HYPERSTIMULATION SYNDROME

Stepan Machaca, Marek Lubuskya, Martin Prochazkaa, Robert Stredab
a Dept. of Obstetrics and Gynecology, University Hospital, Olomouc, Czech Republic
b Centre of Assisted Reproduction SANUS, Hradec Kralove, Czech Republic

Background and objective: To determine the prevalence of markers of inherited thrombophilia in patients with severe form of ovarian hyperstimulation syndrome (OHSS) Design and methods: Blood samples were analysed for markers of thrombophilia (mutation of factor V - Leiden, mutation of methylentetrahydrofolat reductase (MTHFR) C677T and mutation of prothrombin G20210A). The study group consisted of women who had undergone controlled ovarian hyperstimulation for IVF complicated by severe OHSS (group A, n = 50). Results were compared with two controls groups - women who underwent ovarian hyperstimulation for IVF without developing OHSS (group B, n = 93) and healthy pregnant women with no history of infertility (group C, n = 196).

Results: We have found 7 out of 50 patients from group A positive for Leiden mutation (heterozygous) 11 out of 93 from group B (heterozygous), p = 0.71 OR 1.21 (0.39 3.70) and 10 out of 196 from group C (heterozygous), p = 0.03 OR 3.03 (0.97 9.28). Polymorphism of MTHFR 677T gene was detected in 17 out of 50 patients (heterozygous) from group A, in 36 out of 93 patients from group B (35 heterozygous, 1 homozygous) and in 93 out of 196 patients from the group C (86 heterozygous, 7 homozygous) with no statistical significance.

Conclusions: We found an increased prevalence of factor V Leiden mutation in Czech infertile women. However carriers of Leiden mutation had no enhanced risk of development severe form of OHSS during stimulation.

Keywords: Ovarian hyperstimulation syndrome, Thrombophilia, Factor V Leiden mutation

Received: September 5, 2006; Accepted: November 17, 2006; Published: December 1, 2006  Show citation

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Machac, S., Lubusky, M., Prochazka, M., & Streda, R. (2006). PREVALENCE OF INHERITED THROMBOPHILIA IN PATIENTS WITH SEVERE OVARIAN HYPERSTIMULATION SYNDROME. Biomedical papers, 150(2), 289-292. doi: 10.5507/bp.2006.044
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    References

    1. Navot D, Bergh P, Leufer N. Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment. Fertil Steril 1992; 58:24961. Go to original source...
    2. Brinsden PR, Wada I, Tan SL, Balen A, Jacobs HS. Diagnosis, prevention and management of ovarian hyperstimulation syndrome. Brit J Obstet Gynecol 1995; 102:76772. Go to original source...
    3. Dulitzki M, Cohen SB, Inbal A, Seidman DS, Soriano D, Lidor A, et al. Increased prevalence of thrombophilia among women with severe ovarian hyperstimulation syndrome. Fertil Steril 2002; 77:4637. Go to original source... Go to PubMed...
    4. Fabregues F, Tassies D, Reverte JC, Carmona F, Ordinas A, Balasch J. Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. Fertil Steril 2004; 81:98995. Go to original source... Go to PubMed...
    5. Paseka J, Unzeitig V, Cibula D. Mutace faktoru V Leiden u uživatelek hormonální antikoncepce. Ces Gynek 2000; 65:1569.
    6. Biron CH, Galtier-Dereure F, Robesandratena H, Bernard I, Hodon B. Hemostasis parameters during ovarian stimulation for in vitro fertilisation: results of a prospective study. Fertil Steril 1997; 67:1049. Go to original source... Go to PubMed...
    7. Kodama H, Fukada J, Karube H, Matsui T, Shimuzu Y, Tanaka T. Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism. Fertil Steril 1995; 64:12079. Go to original source... Go to PubMed...
    8. Delvigne A, Kostyla K, De Leener A. Metabolic characteristics of women who developed ovarian hyperstimulation syndrome. Hum Reprod 2002; 17:19946. Go to original source... Go to PubMed...
    9. Svensson PJ, Dahlback . Resistence to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia. Haematologia 1995; 80:34456.
    10. Tsanadis G, Vartholomatos G, Korkontzelos I, Avgoustatos F, Kakosimos G, Sotiriadis A. Polycystic ovarian syndrome and thrombophilia. Hum Reprod 2002; 17:3149. Go to original source... Go to PubMed...
    11. Alfirevic Z, Mousa HA, Martlew V. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol 2001; 97:75359. Go to original source... Go to PubMed...
    12. Alfirevic Z, Roberts D, Martlew V. How strong is the association between maternal thrombophilia and reverse pregnancy outcome? A systematic review. Eur J Obst Gynecol Reprod Biol 2002; 101:6 14. Go to original source...
    13. Lindquist P, Dählback B, Marsal K. Thrombotic risk during pregnancy: A population study. Obstet Gynecol 1999; 94:5959. Go to original source...
    14. Azem F, Many A, Ben Ami I, Yovel I, Amit A, Lessing J B, et al. Increased rates of thrombophilia in women with repeated IVF failures. Hum Reprod 2004; 19:36870 Go to original source... Go to PubMed...
    15. Martinelli I, Taioli E, Ragni G, Levi -Setti P, Passamonti SM, Battaglioli T. Embryo implantation after assisted reproduction procedures and maternal thrombophilia. Haematologica 2003; 88:78993. Go to original source...
    16. Vaquero E, Lazzarin N, Caserta D, Valensise H, Baldi M, Moscarini M, et al. Diagnostic evaluation of women experiencing repeated in vitro fertilisation failure. Eur J Gynecol Reprod Biol 2005; 10:12535.
    17. Machac S, Lubusky M, Prochazka M. Prevalence of Inherited Thrombophilia in Patients with Severe Ovarian Hyperstimulation Syndrome. Proceedings of the 22nd ESHRE annual meeting, 2006, 1821 June; Prague, Czech Republic. Oxford University Press, 2006. p. i143i144.

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