Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(2):223-226 | DOI: 10.5507/bp.2006.031

CORTICAL PLASTICITY AND ITS IMPLICATIONS FOR FOCAL HAND DYSTONIA

Robert Opavsky, Petr Hlustik, Petr Kanovsky
Department of Neurology, Palacky University, University Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic

Background: The exact origin of focal dystonias has not been elucidated so far. Aberrant plasticity of the brain cortex is suspected to be a crucial factor in the development of this group of movement disorders. The aim of this article is to summarize recent findings on the etiopathogenesis of focal hand dystonias with a focus on the role of abnormal cortical plasticity.

Methods And Results: A search of the literature mainly from 1995 to 2005 was done using the PubMed and Ovid search engines. English-language articles were identified using the following keywords: focal hand dystonia or writer's cramp and cortical plasticity, sensorimotor, imaging. Additional references were found through bibliography reviews of relevant articles. The data from neurophysiological and imaging studies, as well as clinical observation, in focal hand dystonia suggest multiple failures at different levels of the somatosensory and motor systems, particularly in the brain cortex. This disorders lead to attenuation of inhibitory and fortification of excitatory processes.

Conclusions: The emerging theory presumes that a maladaptive plasticity of brain cortex with abnormal sensorimotor intergration can evolve in predisposed individuals. Consequent methods of management of focal hand dystonias are outlined.

Keywords: Focal hand dystonia, Cortical plasticity, Sensorimotor integration, Botulinum toxin

Received: October 10, 2006; Accepted: November 20, 2006; Published: December 1, 2006  Show citation

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Opavsky, R., Hlustik, P., & Kanovsky, P. (2006). CORTICAL PLASTICITY AND ITS IMPLICATIONS FOR FOCAL HAND DYSTONIA. Biomedical papers150(2), 223-226. doi: 10.5507/bp.2006.031
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References

  1. Nudo RJ. Retuning the misfiring brain. Proc. Natl. Acad. Sci. USA 2003; 100:7425-7427. Go to original source...
  2. Hebb DO, The Organization of Behavior: A Neuropsychological Theory. New York: John Wiley and Sons; 1949.
  3. Johansson BB. Brain plasticity in health and disease. Keio J Med 2004; 53:231-246. Go to original source... Go to PubMed...
  4. Rakic P. Neurogenesis in adult primate neocortex: an evaluation of the evidence. Nature Reviews Neuroscience 2002; 3:65-71. Go to original source... Go to PubMed...
  5. Darian-Smith C, Gilbert CD. Axonal sprouting accompanies functional reorganization in adult cat striate cortex. Nature 1994; 6473:737-40. Go to original source... Go to PubMed...
  6. Calford MB, Tweedale R. Immediate and chronic changes in response of somatosensory cortex in adult flying-fox after digit amputation. Nature 1988; 6163:446-8. Go to original source... Go to PubMed...
  7. Stanton PK, Schanne FA. Hippocampal long-term potentiation increases mitochondrial calcium pump activity in rat. Brain Res 1986; 382:185-188. Go to original source... Go to PubMed...
  8. Kara P, Friedlander MJ. Dynamic modulation of cerebral cortex synaptic function by nitric oxide. Prog Brain Res 1998; 118:183- 198. Go to original source... Go to PubMed...
  9. Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 2002; 420:788-794. Go to original source... Go to PubMed...
  10. Segal K. Dendritic spines and long-term plasticity. Nature Rev Neurosci 2005; 6:277-284. Go to original source... Go to PubMed...
  11. Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthized rabbit following stimulation of the perforant path. J Physiol 1973; 232:331-56. Go to original source... Go to PubMed...
  12. Baranyi A, Feher O. Synaptic facilitation requires paired activation of convergent pathways in the neocortex. Nature 1981; 5808:413- 5. Go to original source... Go to PubMed...
  13. Gage FH. Mammalian neural stem cells. Science 2000; 287:1433- 1438. Go to original source... Go to PubMed...
  14. Chvatal A, Sykova E. Glial influence on neuronal signaling. Prog Brain Res 2000; 125:199-216 Go to original source... Go to PubMed...
  15. Tinazzi M, Rosso T, Fiaschi A. Role of the Somatosensory System in Primary Dystonia: Mov Disord 2003; 6:605-622. Go to original source...
  16. Byl NN, Marzenich MM, Jenkins WM. A primate genesis model of focal dystonia and repetitive strain injury: I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys. Neurology 1996; 47:508- 520. Go to original source... Go to PubMed...
  17. Quartarone A, Bagnato S, Rizzo V, Siebner HR, Dattola V, Scalfari A, Morgante F, Battaglia F, Romano M, Girlanda P. Abnormal associative plasticity of the human motor cortex in writers cramp. Brain 2003; 12:2586-2596. Go to original source... Go to PubMed...
  18. Leis AA, Dimitrijevic MR, Delapasse JS, Sharkey PC. Modification of cervical dystonia by selective sensory stimulation. J Neurol Sci 1992; 110:79-89. Go to original source... Go to PubMed...
  19. Defazio G, Baradelli A, Abbruzzese G et al. Possible risk factors for primary adult onset dystonia: a case control investigation by the Italian Movement Disorders Study Group. J Neurol Neurosurg Psychiatry 1998; 64:25-32. Go to original source... Go to PubMed...
  20. Sanger TD, Tarsy D, Pasqual-Leone A. Abnormalities of spatial and temporal sensory discrimination in writers cramp. Mov Disord 2001; 16:94-99. Go to original source... Go to PubMed...
  21. Tinazzi M, Priori A, Bertolasi L, Frasson E, Mauguiere F, Fiaschi A. Abnormal central integration of a dual somatosensory input in dystonia. Evidence of sensory overflow. Brain 2000; 1:42-50. Go to original source... Go to PubMed...
  22. Elbert T, Candia V, Altenmuller E, Rau H, Sterr A, Rockstroh B et al. Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport 1998; 9:3571-3575 Go to original source... Go to PubMed...
  23. Maunier S, Garnero L, Ducorps A, Mazieres L, Lehericy S et al. Human Brain Mapping in Dystonia Reveals Both Endophenotypic Traits and Adaptive Reorganization. Ann Neur 2001; 50:521- 527. Go to original source... Go to PubMed...
  24. Rome SM, Grünewald RA. Perception of vibration-induced ilusionary movement in first-degree relatives of patients with dystonia. Mov Disord 2000; 15(Suppl 3):140. Go to PubMed...
  25. Preibisch C, Berg D, Hofmann E, Solymosi L, Neumann M. Cerebral activation patterns in patients with writers cramp: functional magnetic resonance imaging study. J Neurol 2001; 248:10- 17. Go to original source... Go to PubMed...
  26. Butterworth S, Francis S, Kelly E, McGlone F, Bowtell R, Sawle GV. Abnormal Cortical Sensory Activation in Dystonia: An fMRI Study. Mov Disord 2003; 6:673-682. Go to original source... Go to PubMed...
  27. Braun C, Schweizer R, Heinz U, Wiech K, Birbaumer N, Topka H. Task-specific plasticity of somatosensory cortex in patients with writers cramp. NeuroImage 2003; 20:1329-1338. Go to original source... Go to PubMed...
  28. Levy LM, Hallet M. Impaired Brain GABA in Focal Dystonia. Ann Neurol 2002; 5:93-101. Go to original source... Go to PubMed...
  29. Garraux G, Bauer A, Hanakawa T, Wu T, Kansaku K, Hallet M. Changes in Brain Anatomy in Focal Hand Dystonia. Ann Neurol 2004; 55:736-739. Go to original source... Go to PubMed...
  30. Lerner A, Shill H, Hanakawa T, Bushara K, Goldfine A, Hallet M. Regional cerebral blood flow correlates of the severity of writerss cramp symptoms. NeuroImage 2004; 21:904-913. Go to original source... Go to PubMed...
  31. Kanovsky P. Dystonia: A Disorder of Motor Programming or.. Motor Execution? 2002; Mov Disord 6:1143-1147. Go to original source... Go to PubMed...
  32. Liepert J, Tegenthoff M, Malin JP. Changes of cortical motor area size during immobilization. Elektroencephalography & Clinical Neurophysiology 1995; 6:382-6. Go to original source...
  33. Facchini S, Romani M, Tinazzi M, Aglioti SM. Time-related changes of excitability of the human motor systém contingent upon immobilisation of the ring and the little fingers. Clinical Neurophysiology 2002; 113:367-375. Go to original source... Go to PubMed...
  34. Byrnes ML, Thickbroom GW, Wilson SA, Sacco P, Shipman JM, Stell R, Mastaglia FL. The corticomotor representation of upper limb muscles in writers cramp and changes following botulinum toxin injection. Brain 1998; 121:977-988. Go to original source... Go to PubMed...
  35. Kanovsky P, Bares M, Streitova H, Klajblova H, Pavel D, Rektor I. The disorder of cortical excitability and cortical inhibition in focal dystonia is normalised following successful botulinum toxin treatment: an evidence from somatosensory evoked potentials and transcranial magnetic stimulation recordings. Neurology 2005; 64 (Suppl 1):A381.