Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(1):85-87 | DOI: 10.5507/bp.2006.010

Guanylins - Agents with natriuretic effect

Pavlina Solichova, David Stejskal, Jitka Proskova
Department of Laboratory Medicine, Hospital Sternberk, Czech Republic

Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl- secretion. A diet high in salt lead especially to increased guanylin and uroguanylin secretion. Interesting applications with guanylins measurement could to be in hypertension diagnosis, monitoring of heart dysfunction treatment, intensive care etc.

Keywords: cGMP, G-C family, Guanylins, Proguanylin, Uroguanylin

Received: July 11, 2005; Accepted: June 23, 2006; Published: July 1, 2006  Show citation

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Solichova, P., Stejskal, D., & Proskova, J. (2006). Guanylins - Agents with natriuretic effect. Biomedical papers, 150(1), 85-87. doi: 10.5507/bp.2006.010
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