Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149(2):401-403 | DOI: 10.5507/bp.2005.068

DEVELOPMENT OF CIPROFLOXACIN RESISTANCE DUE TO CHROMOSOMAL MUTATIONS INDUCED BY 2-NITROFLUORENE

Lucia Birošová, Mária Mikulášová
Department of Biochemistry and Microbiology, Faculty of Food and Chemical Technology, Slovak University of Technology, Bratislava, Slovakia

In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.

Keywords: 2-Nitrofluorene, Antibiotic resistance, Ciprofloxacin, Salmonella typhimurium

Received: June 10, 2005; Accepted: September 25, 2005; Published: December 1, 2005  Show citation

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Birošová, L., & Mikulášová, M. (2005). DEVELOPMENT OF CIPROFLOXACIN RESISTANCE DUE TO CHROMOSOMAL MUTATIONS INDUCED BY 2-NITROFLUORENE. Biomedical papers, 149(2), 401-403. doi: 10.5507/bp.2005.068
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    References

    1. IARC (International Agency for Research on Cancer) Monographs on the Evaluation of the Carcinogenic Risks to Humans. In: Diesel and Gasoline Engine Exhausts and Some Nitroarenes, vol 46. Lyon: International Agency for Research on Cancer, 1989.
    2. Fu PP. (1990) Metabolism of nitro-polycyclic aromatic hydrocarbons. Drug Metab Rev 22, 209-68. Go to original source... Go to PubMed...
    3. Purohit V, Basu AK. (2000) Mutagenicity of nitroaromatic compounds. Chem Res Toxicol 13, 673-92. Go to original source... Go to PubMed...
    4. Lankaputhra WEV, Shah NP. (1998) Antimutagenic properties of probiotic bacteria and of organic acids. Mut Res 397, 169-82. Go to original source...
    5. Davies J, Wright GD. (1997) Bacterial resistance to aminoglycoside antibiotics, Trends Microbiol 5, 234-40. Go to original source... Go to PubMed...
    6. Hogan D, Kolter R. (2002) Why are bacteria refractory to antimicrobials? Current Opinion Microbiol 5, 472-7. Go to original source... Go to PubMed...
    7. Pidock LJ. (2002) Fluroquinolone resistance in Salmonella serovars isolated from humans and food animals. FEMS Microbiol Rev 26, 3-16. Go to original source... Go to PubMed...
    8. Cloeckaert A, Chaslus-Dancla E. (2001) Mechanism of quinolone resistance in Salmonella. Vet Res 32, 291-300. Go to original source... Go to PubMed...
    9. Tauxe RV. Epidemiology of Salmonella. In: Oral communication presented at session 94 of the 92nd General Meeting of the American Society for Microbiology. Washington DC, American Society for Microbiology, 1992.
    10. Barnass S, Franklin J, Tabaqchali S. (1990) The successful treatment of multiresistant non-enteric salmonellosis with seven day oral ciprofloxacin. J Antimicrob Chemother 25, 299-300. Go to original source... Go to PubMed...
    11. Cherubin CE, Eng RHK. (1991) Quinolones for the treatment of infections due to Salmonella. Rev Infect Dis 13, 343-44. Go to original source... Go to PubMed...
    12. Reid TMS. (1992) The treatment of non-typhi salmonellosis. J Antimicrob Chemother 29, 4-8. Go to original source... Go to PubMed...
    13. Shah PM. (1989) Use of quinolone for the treatment of patients with bacteremia. Rev Infect Dis 11 (Suppl. 5), S1156-9. Go to original source... Go to PubMed...
    14. Fisher IST. (1997) Salmonella enteritidis and S. typhimurium in Western Europe for 1993-1995: a surveillance report from Salm- Net. Eurosurveillance 2, 4-6. Go to original source... Go to PubMed...
    15. Threlfall EJ, Ward LR, Rowe B. (1997) Increasing incidence of resistance to trimethoprime and ciprofloxacin in epidemic Salmonella typhimurium DT 104. Eurosurveillance 2, 81-3. Go to original source... Go to PubMed...
    16. Cohen SP, McMurry LM, Levy SB. (1988) marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. J Bacteriol 170, 5416-22. Go to original source... Go to PubMed...
    17. Rajyaguru JM, Muszynski MJ. (1997) Association of resistance to trimethoprim/sulphamethoxazole, chloramphenicol and quinolones with changes in major outer membrane proteins and lipopolysaccharide in Burkholderia cepacia. J Antimicrob Chemother 40, 803-9. Go to original source... Go to PubMed...
    18. Nikaido H, Basina M, Nguyen V, Rosenberg EY. (1998) Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains. J Bacteriol 180, 4686-92. Go to original source... Go to PubMed...
    19. Maron D, Ames B. (1983) Revised methods for the Salmonella mutagenicity test. Mutat Res 113, 173-215. Go to original source... Go to PubMed...
    20. Fedorka-Cray PJ, Miller M, Tollefson L, Dargatz DA, Wineland NE. National Antimicrobial Susceptibility Monitoring Program - Veterinary Isolates. Washington DC: United States Government Printing, 1998.
    21. Monteiro ACM, Ferreira RCC, Padilla LCS, Costa SOP. (2003) Environmental and genetic factors affecting mutability to aminoglycoside antibiotics among Escherichia coli K12 strains. Genetic and Molecular Biology 26, 221-7. Go to original source...

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