Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149(2):339-343 | DOI: 10.5507/bp.2005.054

EFFECT OF A NEW ULTRASHORT BETALYTIC AGENT ON ACONITINE-INDUCED ARRHYTHMIA

Ladislava Bartošová^a, Filip Novák^a, Marek Frydrych^a, Tomáš Parák^a, Radka Opatřilová^b, Vít Brunclík^c, Jana Kolevská^c, Elnaggar El Moataz^a, Jiří Nečas^a

^a Department of Human Pharmacology and Toxicology,

^b Department of Chemical Drugs, Pharmaceutical Faculty, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic

^c Clinic of Canine and Feline Diseases, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic

The anti-arrhythmic effect was tested on the model of aconitine-induced arrhythmia. The experiment was performed in vivo with 31 male Wistar laboratory rats. Group A was first administered aconitine and, after the onset of the first sinus rhythm disorders, the 44Bu compound was administered. Group B was first administered the 44Bu compound and only after that the aconitine. The control group was administered aconitine and saline as a replacement of the tested compound. In group A, there was a decrease in the ventricular fibrillation occurrence from 100 % to 8 % (p < 0.001) after the administration of the 44Bu compound. In the B group, the onsets of all monitored arrhythmia types were delayed by an average of 15.6 min. Ventricular rhythm occurrence was decreased from 100 to 20 %, as well as ventricular fibrillations, from 100 to 0 % (p < 0.001).

Keywords: Experimental pharmacology, Rats, Ester-functional group, Aconitine, Ventricular fibrillations

Received: June 10, 2005; Accepted: September 25, 2005; Published: December 1, 2005  Show citation