Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149(1):141-144 | DOI: 10.5507/bp.2005.016

p53 - Prognostic factor of malignant transformation of barrett's esophagus

René Aujeský R*a, Marián Hajdúch*b, Čestmír Neorala, Vladimír Krála, Lucie Ľubušskác, Tomáš Bohanesa, Jiří Kleina, Radek Vrbaa, Petr Dráčd
a 1st Clinic of Surgery, Teaching Hospital Olomouc, Czech Republic
b Laboratory of Experimental Medicine, Department of Pediatrics, Faculty of Medicine, Palacky University and Teaching Hospital Olomouc, Czech Republic
c Department of Surgical Intensive Care, Teaching Hospital Olomouc, Czech Republic
d 2nd Clinic of Surgery, Teaching Hospital Olomouc, Czech Republic
Both authors equally contributed to the work

The most significant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformation is determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indication of "preventive" extirpation of the esophagus should be supported by other factors, for example by detection of p53 mutation or expression. The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Department of Surgery, the p53 level and its correlation with histological findings evaluated in these patients. A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlation was also confirmed by detection of early carcinoma in patients with "preventive" extirpation of the esophagus due to a high-grade dysplasia. Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may be helpful for the estimation of malignant potential of the dysplastic mucosa.

Keywords: Keywords: Esophagus, Esophageal cancer, p53, Barrett’s esophagus

Received: May 16, 2005; Accepted: June 30, 2005; Published: July 1, 2005  Show citation

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Aujeský, R.R., Hajdúch, M., Neoral, Č., Král, V., Ľubušská, L., Bohanes, T., ... Dráč, P. (2005). p53 - Prognostic factor of malignant transformation of barrett's esophagus. Biomedical papers, 149(1), 141-144. doi: 10.5507/bp.2005.016
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