Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149(1):89-91 | DOI: 10.5507/bp.2005.010

MCL-1 (myosin light chains-1) in differential diagnosis of dyspnea

David Stejskala, Bořek Lačňákb, Kateřina Andelováa, Marcela Škvařilovác, Josef Bartekd
a Department of Laboratory Medicine, Hospital Šternberk, Czech Republic
b Department of Internal Medicine, Hospital Šternberk, Czech Republic
c 2nd Clinic of Internal Medicine, Faculty Hospital Charles University Prague, Czech Republic
d Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University Olomouc, Czech Republic

Myosin light chains-1 (MLC-1) have been recently associated with the markers of heart function (NYHA, LVEF, NT-proBNP). Verification of the relationship between markers of heart function (New York Heart Association classification (NYHA), left ventricle ejection fraction determination (LVEF), N terminal prohormone of natriuretic peptide B type BNP (NT-proBNP) and concentrations of myosin light chains-1 (MLC-1) was assesed. Patients examined for dyspnea without signs of acute coronary syndrome. All patients underwent echocardiography (calculation of left ventricle ejection fraction - LVEF) and in the serum of all subjects NT-proBNP (ELEIA) and MLC-1 (ELISA) were determined. In the 38 patients (21 men, 17 women), mean age of 58 years (±12 years as 1 SD), a significant negative correlation was found between NT-proBNP and LVEF (r = - 0.47; p = 0.02, Spearman). The median levels of NT pro-BNP were closely associated with NYHA classification (type II - 584 ng/l, type III - 2792 ng/l, type IV - 6400 ng/l; p < 0.05). Individuals with clinical NYHA IV differed significantly in median MLC-1 concentrations from persons with clinical NYHA classification II and III (type II - 5.7 ng/l, type III - 8.9 ng/l, type IV - 17 ng/l; p < 0.05). A significant negative correlation between MLC-1 and LVEF (- 0.35; p < 0.03) and significant positive correlations between MLC-1 and NT-proBNP (- 0.42; p < 0.012) were found. In conclusion MLC-1 cannot be used as a diagnostic marker in differential diagnosis of dyspnea.

Keywords: MLC-1, NT-proBNP, Dyspnea, Heart failure

Received: April 7, 2005; Accepted: June 3, 2005; Published: July 1, 2005  Show citation

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Stejskal, D., Lačňák, B., Andelová, K., Škvařilová, M., & Bartek, J. (2005). MCL-1 (myosin light chains-1) in differential diagnosis of dyspnea. Biomedical papers, 149(1), 89-91. doi: 10.5507/bp.2005.010
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