Acta Univ. Palacki. Olomuc., Fac. Med. Volume 144, 2000 | DOI: 10.5507/bp.2000.018
EARLY RENAL FAILURE AFTER MESALAZINE (CASE REPORT)
- 2nd Internal Clinic University Hospital, Palackż University Olomouc, Czech Republic
An early onset of asymptomatic renal failure in a young man with ulcerative colitis treated with high-dosemesalazine is the subject of this case report. After mesalazine withdrawal, renal function was quickly restored. Incontrast with published case reports, the onset of renal impairment occurred very early. Serum urea reachedpathological values 27 days and serum creatinine 15 days after mesalazine treatment was started. The diagnosis ofrenal impairment was supported by urine analysis (both semi-quantitative and quantitative) and dynamic renalisotope scanning.
Keywords: 5-Aminosalicylic acid, Mesalazine, Renal failure, Tubuloinerstitial nephritis, Ulcerative colitis
Published: December 1, 2000 Show citation
References
- Brouillard, M., Katz, K. O., Henning, N. P., Reimann, D. S., Myers, B. (1998): Chronic interstitial nephritis and mesalazine: 3 new cases? Gastroenterol. Clin. Biol., 22, 724-726.
Go to PubMed...
- Popoola, J., Muller, A. F., Pollock, L., ODonnell, P., Carmichael, P., Stevens, P. (1998): Late onset interstitial nephritis associated with mesalazine treatment. BMJ, 317, 795-797. DOI: 10.1136/bmj.317.7161.795
Go to original source...
Go to PubMed...
- Calvino, J., (1998): Mesalazine-associated tubulo-interstitial nephritis in inflammatory bowel disease. Clin. Nephrol., 49, 265-267.
Go to PubMed...
- Noble, E., Janssen, L., Dierick, P. J. (1997): Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines. Cell. Biol. Toxicol., 13, 445-451.
Go to original source...
Go to PubMed...
- Hamling, J., Raedler, A., Helmchen, U., Schreiber, S. (1997): 5-Aminosalicylic acid-associated renal tubular acidosis with decreased renal function in Crohns disease. Digestion, 58, 304-307. DOI: 10.1159/000201459
Go to original source...
Go to PubMed...
- World, M. J., Stevens, P. E., Ashton, M. A., Rainford, D. J. (1996): Mesalazine-associated interstitial nephritis. Nephrol. Dial. Transplant., 11, 614-621.
Go to original source...
Go to PubMed...
- Garcia-Diaz, M., (1995): Acute renal failure associated with 5-aminosalicylic acid in inflammatory bowel disease. Gastroenterol. Hepatol., 18, 18-21.
Go to PubMed...
- Smilde, T. J., van Liebergen, F. J., Koolen, M. I., Gerlag, P. G., Assman, K. J., Berolen, J. H. (1994): Tubulointerstitial nephritis caused by mesalazine (5-ASA) agents. Ned. Tijdschr. Geneeskd., 138, 2557-2561.
- Thuluvath, P. J., Ninkovic, M., Calam, J., Anderson, M. (1994): Mesalazine induced intersticial nephritis. Gut, 35, 1493-1496. DOI: 10.1136/gut.35.10.1493
Go to original source...
Go to PubMed...
- Novis, B. H., Korzets, Z., Chen, P., Bernheim, J. (1988): Nephrotic syndrome after treatment with 5-aminosalicylic acid. BMJ, 296, 1442. DOI: 10.1136/bmj.296.6634.1442
Go to original source...
Go to PubMed...
- Barbour, V. M., Williams, P. F. (1990): Nephrotic syndrome associated with sulphasalazine. BMJ, 301, 818. DOI: 10.1136/bmj.301.6755.818-b
Go to original source...
Go to PubMed...
- Calder, I. C., Funder, C. C., Green, C. R., Ham, K. N., Tange, J. D. (1972): Nephrotoxic lesions from 5-aminosalicylic acid. Br. Med. J., 1, 152-154.
Go to original source...
Go to PubMed...