Acta Univ. Palacki. Olomuc., Fac. Med. Volume 144, 2000 | DOI: 10.5507/bp.2000.012

CONCENTRATION OF SOLUBLE LEPTIN RECEPTOR IN POPULATION

Josef Bartekc, David Stejskala,b, Pavel Stejskald, Ivo Oralb
a Department of Laboratory Medicine, Hospital ©ternberk
b Department of Internal Medicine, Hospital ©ternberk
c Department of Clinical Chemistry and Biochemistry, Medical Faculty, Palackı University, 775 15 Olomouc
d Faculty of Physical Culture, Palackı University, Olomouc, Czech Republic

Examinations were performed in 568 probands (217 men, 351 women) selected randomly from healthypopulation according to the following criterion: no treatment in the last six weeks for any disease. All probandswere subjected to determination of BMI, cholesterol, triacylglycerols, LDL-cholesterol, intact proinsulin, insulin,uric acid, ALT, AST, GMT, LD, CRP, aterogenic plasma index, leptin, and soluble leptin receptor. We determinedconcentration of soluble leptin receptor in population sample of 560 probands. A positive correlation betweenleptinemia and BMI value was confirmed. It was found that Ob-Re concentration did not correlate with commonanthropometrical parameters nor leptin concentration in the serum, but correlated negatively only with insulin andplasma aterogenity. This finding indicates an increased presence of free leptin in patients with signs of insulin(therefore also leptin) resistance.

Keywords: Leptin receptor, Concentration of leptin receptor in population

Published: December 1, 2000  Show citation

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Bartek, J., Stejskal, D., Stejskal, P., & Oral, I. (2000). CONCENTRATION OF SOLUBLE LEPTIN RECEPTOR IN POPULATION. Biomedical papers, 144(144), 7-10. doi: 10.5507/bp.2000.012
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    References

    1. Bornstein, S. R. et al. (2000) Immunohistochemical and Ultrastructural Localization of Leptin and Leptin receptor in Human White Adipose. Tissue Diabetes, 49, 4, 532-538. Go to original source... Go to PubMed...
    2. Chen, X., Lin, J., Hausman, D. B. et al. (2000) Alterations in fetal Adipose Tisse Leptin Expression Correlate with the Development af Adipose Tissue. Biol. Neonat, 78, 1, 41-47. Go to original source...
    3. Quinton, N. D., Smith, R. F., Clayton, P. E., Gill, M. S. et al. Leptin Binding Activity Changes with Age: The link between Leptin and Puberty. J. Clin. Endocrinol. Metab, 84, 7, 2336-2341. Go to original source...
    4. Udagawa, J., Hatta, T., Naora, H. et al (2000) Expression of the long form of leptin receptor (Ob-Rb) mRNA in the brain of mouse embryos and newborn mice. Brain Res., 868, 2, 251-258. Go to original source... Go to PubMed...
    5. Jin, L., Zhang, S., Burguera, B.G. et al. (2000) Leptin and leptin receptor expression in rat and mouse pituitary cells. Endocrinology, 141, 1, 333-339. Go to original source... Go to PubMed...
    6. Stejskal, D., Bartek, J., Ruzicka, V. (1999) Determination of leptin receptor in the serum and relations to laboratory and anthropological parameters in patients with atherosclerotic complications. Acta Univ. Palacki Fac. Med., 142, 89-92.
    7. Lewandowski, K., Horn, R., OCallaghan, C. J. et al. (1999) Free leptin, bound Leptin, and soluble Leptin receptor in normal and diabetic pregnancies. J. Clin. Endocrinol. Metab., 84, 1, 300-306. Go to original source... Go to PubMed...
    8. Oguich, O., Sooranna, S., Nicolaides, K. H. et al. (2000) The relationship between leptin concentration and bone metabolism in the human fetus. J. Clin. Endocrinol. Metab., 85, 56, 1997-1999. Go to original source... Go to PubMed...
    9. Laivuori, H., Kaaja, R., Koistinen, H. et al. (2000) Leptin during and after preeclamptic of normal pregnancy. Metabolism, 49, 2, 259-263. Go to original source... Go to PubMed...
    10. Diamond, F. (2000) Leptin binding activity in plasma of nondiabetic and diabetic adolescents and obese children. J. Pediatr. Endocrinol. Metab., 13, 2, 141-148. Go to original source... Go to PubMed...

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