Acta Univ. Palacki. Olomuc., Fac. Med. Volume 143, 2000 | DOI: 10.5507/bp.2000.001

CHEMOKINE RECEPTORS

Agáta Gibejová
Department of Immunology, Medical Faculty of Palacký University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic

Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamilyof rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve ascoreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation. Thisreview aims at summarising data on chemokine receptors, their function in vivo, their target cells and it alsomentions association of chemokine receptor polymorphisms with human disease.

Keywords: Chemokines, Chemokine receptors, Polymorphisms, Knockout mice, Function in vivo

Published: July 1, 2000  Show citation

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Gibejová, A. (2000). CHEMOKINE RECEPTORS. Biomedical papers, 144(143), 9-18. doi: 10.5507/bp.2000.001
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