Acta Univ. Palacki. Olomuc., Fac. Med. Volume 141, 1998

EFFECT OF SILYMARIN ON SERUM CHOLESTEROL LEVELS IN RATS

Nina ©kottová, Vladimír Kreèman, Daniela Walterová, Jitka Ulrichová, Pavel Kosina, Vilím ©imánek
Institute of Medical Chemistry, Medical Faculty, Palacký University, 775 15 Olomouc, Czech Republic.

Previously we have shown that perorally administered silymarin, a mixture of flavonolignans extracted from the seeds ofSilybum marianum, possesses a hypocholesterolemic effect in rats fed high cholesterol diet enriched with fat1. The aim ofthis paper was to complete the data concerning peroral and parenteral administration of silymarin. The rats fed standardlaboratory diet did not respond to peroral administration of silymarin by decrease of serum cholesterol, but the mild increasein HDL cholesterol was found. Parenterally injected silymarin failed to reduce serum cholesterol both in rats fed highcholesterol diet and standard laboratory diet. The results suggest that silymarin could act either due to the fat-mediatedimproved bioavailability and/or by inhibiting of resorption of dietary cholesterol.

Keywords: Silymarin, Serum cholesterol, High cholesterol diet

Published: July 1, 1998  Show citation

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©kottová, N., Kreèman, V., Walterová, D., Ulrichová, J., Kosina, P., & ©imánek, V. (1998). EFFECT OF SILYMARIN ON SERUM CHOLESTEROL LEVELS IN RATS. Biomedical papers, 141(1), 
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    References

    1. Kreèman, V., ?kottová, N., Walterová, D., Ulrichová, J., ?imánek, V. (1998) Silymarin inhibits the development of diet-induced hypercholesterolemia in rats. Planta Med. 64, 138?142. Go to original source... Go to PubMed...
    2. Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., Meryn, S., Base, W., Schneider, B. (1989) Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J. Hepatol. 9, 105-113. Go to original source... Go to PubMed...
    3. Morazzoni, P., Bombardelli, E.(1995) Silybum marianum (Cardus marianus). Fitoterapia 66, 6-42.
    4. Valenzuela, A., Garrido, A. (1994) Biochemical bases of the pharmacological action of the flavonoid silymarin and its structural isomer silibinin. Biol. Res. 27, 105-112.
    5. Havel, R. J. (1986) Role of the liver in lipoprotein catabolism. In Methods in Enzymology (Segrest, J. P., Albers, J. J., eds), Academic Press, London, Vol. 129, pp. 591-612. Go to original source...
    6. Steinberg, D., Pathasarathy, S., Carew, T. E., Khoo, J. C., Witztum, J. L. (1989) Modifications of low-density lipoprotein that increase atherogenicity. N. Engl. J. Med. 320, 915-924. Go to original source...
    7. Miller, G. J., Miller, N. E. (1975) Plasma high density lipoprotein concentration and the development of ischemic heart disease. Lancet I, 16-19. Go to original source...
    8. Petronelli, A., Roda, E., Briganti, M., Morselli-Labate, A. M., Barbara, L. (1981) Effect of the administration of silymarin on serum lipid levels. Clin. Ter. 99, 471-482. Go to PubMed...
    9. Somogyi, A., Ecsedi, G. G., Blazovics, A., Miskolczi, K., Gergely, P., Feher, J. (1989) Short term treatment of type II hyperlipoproteinemia with silymarin. Acta Med. Hung. 46, 289-295. Go to PubMed...
    10. Rui, Y. C. (1991) Advances in pharmacological studies of silymarin. Mem. Inst. Oswaldo Cruz 86, 79?85. Go to original source... Go to PubMed...
    11. Nassuato, G., Iemmolo, R. M., Lirussi, F., Orlando, R., Giacon, L., Venuti, M., Strazzabosco, M., Csomos, G., Okolicsanyi, L. (1983) Effect of silybin on biliary lipid composition in rats. Pharmacol. Res. Commun. 15, 337-346. Go to original source... Go to PubMed...
    12. Kostner, G. M., Molinari, E., Piechler, P. (1985) Evaluation of a new HDL2/HDL3 quantitation method based on precipitation with polyaethylene glycole. Clin. Chim. Acta 148, 139-147. Go to original source... Go to PubMed...
    13. ?kottová, N., Veèeøa, R., Walterová, D., ?imánek, V. (1992) The effect of N-deacetylcolchiceine on serum lipoproteins in rats. Planta Med. 58, 26?30. Go to original source... Go to PubMed...
    14. Morazzoni, P., Magistretti, M. J., Giachetti, C., Zanolo, G. (1992) Comparative bioavailability of silipide, a new flavanolignan complex, in rats. Eur. J. Drug Metab. Pharmacokinet. 17, 39-44. Go to original source... Go to PubMed...
    15. Drozdik, M., Juzwiak, S., Machoy-Mokrzynska, A., Wojcicki, J., Kaldonska, M., Mysliwiec, Z., Juzyszyn, Z., Skowron, J., Rozewicka, L., Mscisz, A., Gorecki, P. (1996) Effect of silymarinphospholipid complex on the liver in rabbits maintained on a high-fat diet. Phytother. Res. 10, 406-409. Go to original source...
    16. Yamamoto, K., Fukuda, N., Shiroi, S., Shiotsuki, Y., Nagata, Y., Tani, T., Sakai, T. (1994) Effects of dietary fat levels on the absorption and tissue accumulation of probucol in the rat. Arzneim. Forsch. Drug Res. 44, 1059-1062.

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