Acta Univ. Palacki. Olomuc., Fac. Med. Volume 141, 1998

PERCUTANEOUS ABSORPTION OF DISOPYRAMIDE, LIDOCAINE AND TRIMECAINE

Jan Příborskýa,b, Katsuya Kikuchic, Kozo Takayamac, Tsuneji Nagaic
a Glaxo Wellcome s.r.o., K Žižkovu 4, 190 00 Prague, Czech Republic
b Institute of Pharmacology, Faculty of Medicine, Palacký University, Hněvotínská 3, 77 515 Olomouc, Czech Republic
c Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan

Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrhytmic drugs disopyramide, lidocaine andtrimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement.The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Othercyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.

Keywords: Antiarrhytmic drugs, Penetration enhancer, Cyclic monoterpenes

Published: July 1, 1998  Show citation

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Příborský, J., Kikuchi, K., Takayama, K., & Nagai, T. (1998). PERCUTANEOUS ABSORPTION OF DISOPYRAMIDE, LIDOCAINE AND TRIMECAINE. Biomedical papers, 141(1), 
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