PT  - JOURNAL ARTICLE
AU  - Karlova Zubata, Ivana
AU  - Smetanova Brozova, Jitka
AU  - Karel, Tomas
AU  - Bacova, Barbora
AU  - Novak, Jan
TI  - High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia
DP  - 2024 Jun 10
TA  - Biomedical papers
PG  - 139--146
VI  - 168
IP  - 2
AID - 10.5507/bp.2023.011
IS  - 12138118
AB  - Aims. Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues. Previous works suggested that MAIT cells survive exposure to cytotoxic drugs in these locations. We sought to determine if they maintain their anti-infective functions after myeloablative chemotherapy. Methods. We correlated the amount of MAIT cells (measured by flow cytometry) in the peripheral blood of 100 adult patients before the start of myeloablative conditioning plus autologous stem cell transplantation with the clinical and laboratory outcomes of aplasia. Results. The amount of MAIT cells negatively correlated with peak C-reactive protein level and the amount of red blood cell transfusion units resulting in earlier discharge of patients with the highest amount of MAIT cells. Conclusion. This work suggests the anti-infectious potential of MAIT cells is maintained during myeloid aplasia.