RT Journal Article
SR Electronic
A1 Chylikova, Jaroslava
A1 Dvorackova, Jana
A1 Tauber, Zdenek
A1 Kamarad, Vojtech
T1 M1/M2 macrophage polarization in human obese adipose tissue
JF Biomedical papers
YR 2018
VO 162
IS 2
SP 79
OP 82
DO 10.5507/bp.2018.015
UL https://biomed.papers.upol.cz/artkey/bio-201802-0002.php
AB Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.