PT  - JOURNAL ARTICLE
AU  - Chylikova, Jaroslava
AU  - Dvorackova, Jana
AU  - Tauber, Zdenek
AU  - Kamarad, Vojtech
TI  - M1/M2 macrophage polarization in human obese adipose tissue
DP  - 2018 Jun 25
TA  - Biomedical papers
PG  - 79--82
VI  - 162
IP  - 2
AID - 10.5507/bp.2018.015
IS  - 12138118
AB  - Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.