RT Journal Article
SR Electronic
A1 Fiserova, Barbora
A1 Kubiczkova, Lenka
A1 Sedlarikova, Lenka
A1 Hajek, Roman
A1 Sevcikova, Sabina
T1 The miR-29 family in hematological malignancies
JF Biomedical papers
YR 2015
VO 159
IS 2
SP 184
OP 191
DO 10.5507/bp.2014.037
UL https://biomed.papers.upol.cz/artkey/bio-201502-0003.php
AB Background: MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies.
Conclusion: Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.