PT  - JOURNAL ARTICLE
AU  - Fiserova, Barbora
AU  - Kubiczkova, Lenka
AU  - Sedlarikova, Lenka
AU  - Hajek, Roman
AU  - Sevcikova, Sabina
TI  - The miR-29 family in hematological malignancies
DP  - 2015 Jun 28
TA  - Biomedical papers
PG  - 184--191
VI  - 159
IP  - 2
AID - 10.5507/bp.2014.037
IS  - 12138118
AB  - Background: MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies.
Conclusion: Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.