RT Journal Article
SR Electronic
A1 Lipkova, Jolana
A1 Bienertova-Vasku, Julie Anna
A1 Spinarova, Lenka
A1 Bienert, Petr
A1 Hlavna, Marian
A1 Pavkova Goldbergova, Monika
A1 Parenica, Jiri
A1 Spinar, Jindrich
A1 Vasku, Anna
T1 Per3 VNTR polymorphism and chronic heart failure
JF Biomedical papers
YR 2014
VO 158
IS 1
SP 080
OP 083
DO 10.5507/bp.2012.069
UL https://biomed.papers.upol.cz/artkey/bio-201401-0012.php
AB Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF).
Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.
Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (P<sub>g</sub>=0.30, P<sub>a</sub>=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; P<sub>g</sub>=0.87, P<sub>a</sub>=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found.
Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.