PT  - JOURNAL ARTICLE
AU  - Lipkova, Jolana
AU  - Bienertova-Vasku, Julie Anna
AU  - Spinarova, Lenka
AU  - Bienert, Petr
AU  - Hlavna, Marian
AU  - Pavkova Goldbergova, Monika
AU  - Parenica, Jiri
AU  - Spinar, Jindrich
AU  - Vasku, Anna
TI  - Per3 VNTR polymorphism and chronic heart failure
DP  - 2014 Apr 1
TA  - Biomedical papers
PG  - 080--083
VI  - 158
IP  - 1
AID - 10.5507/bp.2012.069
IS  - 12138118
AB  - Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF).
Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.
Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (P<sub>g</sub>=0.30, P<sub>a</sub>=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; P<sub>g</sub>=0.87, P<sub>a</sub>=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found.
Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.