PT Journal
AU Lipkova, J
   Bienertova-Vasku, J
   Spinarova, L
   Bienert, P
   Hlavna, M
   Pavkova Goldbergova, M
   Parenica, J
   Spinar, J
   Vasku, A
TI Per3 VNTR polymorphism and chronic heart failure
SO Biomedical papers
PY 2014
BP 080
EP 083
VL 158
IS 1
DI 10.5507/bp.2012.069
DE circadian clock; Per3; polymorphism; case-control study; chronic heart failure
AB Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF).Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (P<sub>g</sub>=0.30, P<sub>a</sub>=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; P<sub>g</sub>=0.87, P<sub>a</sub>=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found.Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.
ER