PT  - JOURNAL ARTICLE
AU  - Hodorova, Ingrid
AU  - Solar, Peter
AU  - Mihalik, Jozef
AU  - Vecanova, Janka
AU  - Adamkov, Marian
AU  - Rybarova, Silvia
TI  - Investigation of tumour supressor protein p53 in renal cell carcinoma patients
DP  - 2014 Apr 1
TA  - Biomedical papers
PG  - 044--049
VI  - 158
IP  - 1
AID - 10.5507/bp.2012.035
IS  - 12138118
AB  - Background: Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC.
Methods: 42 tissue sections of RCC and 5 samples of normal renal tissue were stained for p53 expression using immunohistochemical assay. The results were analyzed in relation to nuclear grade and histopathologic subtype.
Results: In total, p53 expression was found to be 4 to 5 times higher (30.8%) in other types of RCC than in the clear-cell type of RCC (6.9%). Further, there was no statistically significant difference in p53 overexpression among the histopathologic subtypes (P>0.05, P=0.063). No association was found between the expression of p53 and nuclear grade (P>0.05, P=0.17). Interestingly, our study also showed weak cytoplasmic positivity in renal tubular epithelium.
Conclusion: Our findings suggest that p53 might play an important role in tumour development or progression and it might be used as a new predictor and therapeutic target for RCC.