RT Journal Article
SR Electronic
A1 Bostikova, Vanda
A1 Salavec, Miloslav
A1 Smetana, Jan
A1 Chlibek, Roman
A1 Kosina, Pavel
A1 Prasil, Petr
A1 Plisek, Stanislav
A1 Splino, Miroslav
A1 Bostik, Pavel
T1 AN UNUSUAL CASE OF MULTI-RECURRENT HERPES ZOSTER (HZ): A CASE REPORT
JF Biomedical papers
YR 2011
VO 155
IS 4
SP 397
OP 401
DO 10.5507/bp.2011.062
UL https://biomed.papers.upol.cz/artkey/bio-201104-0013.php
AB Aims: We report a case of multi-recurrent herpes zoster in a 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over the years 2009 - 2011. Methods: Specific PCR methods targeting single nucleotide polymorphisms (SNPs) in open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons in ORF 22 and/or ORF 21/ORF 50. Additional genotyping in ORF 1, 6, 9 and 28 was subsequently performed due to the unusual results. Results: Three sets of clinical specimens from one patient (from hospital visits 2, 3 and 4) were analyzed and the presence of an unusual wild-type strain of VZV was discovered. The VZV strain isolated from the lesions bears a combination of markers characteristic both for Mosaic 2 (M2) and European 1 (E1) wild-type VZV strains. Conclusion: This is the first report of atypical wild-type VZV strain circulating currently in Czech Republic.