PT  - JOURNAL ARTICLE
AU  - Bostikova, Vanda
AU  - Salavec, Miloslav
AU  - Smetana, Jan
AU  - Chlibek, Roman
AU  - Kosina, Pavel
AU  - Prasil, Petr
AU  - Plisek, Stanislav
AU  - Splino, Miroslav
AU  - Bostik, Pavel
TI  - AN UNUSUAL CASE OF MULTI-RECURRENT HERPES ZOSTER (HZ): A CASE REPORT
DP  - 2011 Dec 1
TA  - Biomedical papers
PG  - 397--401
VI  - 155
IP  - 4
AID - 10.5507/bp.2011.062
IS  - 12138118
AB  - Aims: We report a case of multi-recurrent herpes zoster in a 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over the years 2009 - 2011. Methods: Specific PCR methods targeting single nucleotide polymorphisms (SNPs) in open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons in ORF 22 and/or ORF 21/ORF 50. Additional genotyping in ORF 1, 6, 9 and 28 was subsequently performed due to the unusual results. Results: Three sets of clinical specimens from one patient (from hospital visits 2, 3 and 4) were analyzed and the presence of an unusual wild-type strain of VZV was discovered. The VZV strain isolated from the lesions bears a combination of markers characteristic both for Mosaic 2 (M2) and European 1 (E1) wild-type VZV strains. Conclusion: This is the first report of atypical wild-type VZV strain circulating currently in Czech Republic.