RT Journal Article
SR Electronic
A1 Pink, Richard
A1 Vondrakova, Jana
A1 Tvrdy, Peter
A1 Michl, Petr
A1 Pazdera, Jindrich
A1 Faber, Edgar
A1 Skoumalova, Ivana
A1 Indrak, Karel
T1 SALIVARY NEUTROPHILS LEVEL AS AN INDICATOR OF BONE MARROW ENGRAFTMENT
JF Biomedical papers
YR 2009
VO 153
IS 4
SP 263
OP 269
DO 10.5507/bp.2009.051
UL https://biomed.papers.upol.cz/artkey/bio-200904-0013.php
AB Aim: The aim of this study was to investigate the neutrophils level in saliva as an adequate alternative to other methods for evaluating the neutrophil engraftment after autologous stem cell transplantation (ASCT) in hemato-oncology.
Method: A total of 35 patients treated for non-Hodgkin's lymphoma or multiple myeloma were stomatologically examined before planned high-dose chemotherapy with ASCT. After removal of potential foci of odontogenic infection all the patients underwent transplantation and during the treatment they were monitored for the level of neutrophils in saliva as a possible early indicator of the neutrophil engraftment. Neutrophil levels in saliva were compared to the neutrophil level in blood and to the degree of oral mucositis (the nurses study).
Results: An increase of salivary neutrophils in the mouth rinse of > 25 x 10^6/l was identified as an early sign of successful neutrophil engraftment that occurred 1 to 2 days before the rise of neutrophils in peripheral blood (> 0.5 x 10^9/l).
Conclusions: Follow-up of neutrophil levels in saliva might be an adequate alternative to other methods for evaluating the neutrophil engraftment after ASCT in hemato-oncology.