PT  - JOURNAL ARTICLE
AU  - Pink, Richard
AU  - Vondrakova, Jana
AU  - Tvrdy, Peter
AU  - Michl, Petr
AU  - Pazdera, Jindrich
AU  - Faber, Edgar
AU  - Skoumalova, Ivana
AU  - Indrak, Karel
TI  - SALIVARY NEUTROPHILS LEVEL AS AN INDICATOR OF BONE MARROW ENGRAFTMENT
DP  - 2009 Dec 1
TA  - Biomedical papers
PG  - 263--269
VI  - 153
IP  - 4
AID - 10.5507/bp.2009.051
IS  - 12138118
AB  - Aim: The aim of this study was to investigate the neutrophils level in saliva as an adequate alternative to other methods for evaluating the neutrophil engraftment after autologous stem cell transplantation (ASCT) in hemato-oncology.
Method: A total of 35 patients treated for non-Hodgkin's lymphoma or multiple myeloma were stomatologically examined before planned high-dose chemotherapy with ASCT. After removal of potential foci of odontogenic infection all the patients underwent transplantation and during the treatment they were monitored for the level of neutrophils in saliva as a possible early indicator of the neutrophil engraftment. Neutrophil levels in saliva were compared to the neutrophil level in blood and to the degree of oral mucositis (the nurses study).
Results: An increase of salivary neutrophils in the mouth rinse of > 25 x 10^6/l was identified as an early sign of successful neutrophil engraftment that occurred 1 to 2 days before the rise of neutrophils in peripheral blood (> 0.5 x 10^9/l).
Conclusions: Follow-up of neutrophil levels in saliva might be an adequate alternative to other methods for evaluating the neutrophil engraftment after ASCT in hemato-oncology.