RT Journal Article
SR Electronic
A1 Kuca, Kamil
A1 Musilek, Kamil
A1 Pohanka, Miroslav
A1 Dohnal, Vlastimil
A1 Patocka, Jiri
T1 REACTIVATION POTENCY OF THE ACETYLCHOLINESTERASE REACTIVATOR OBIDOXIME IS LIMITED
JF Biomedical papers
YR 2009
VO 153
IS 4
SP 259
OP 262
DO 10.5507/bp.2009.044
UL https://biomed.papers.upol.cz/artkey/bio-200904-0005.php
AB Background: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial.
Aim: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited.
Method: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. Results and Conclusion: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.