RT Journal Article
SR Electronic
A1 Kotaska, Karel
A1 Popelova, Jana
A1 Tiserova, Marie
A1 Telekes, Peter
A1 Vrzanova, Marie
A1 Bronsky, Jiri
A1 Halacova, Milada
A1 Kukacka, Jiri
A1 Prusa, Richard
T1 THE RELEVANCE OF BRAIN NATRIURETIC PEPTIDES INVESTIGATION IN VARIOUS CARDIOVASCULAR DISEASES
JF Biomedical papers
YR 2006
VO 150
IS 2
SP 285
OP 288
DO 10.5507/bp.2006.043
UL https://biomed.papers.upol.cz/artkey/bio-200602-0016.php
AB Background: Brain natriuretic peptides are relevant markers of heart impairment.
Aim: We investigated the relevance of investiging brain natriuretic peptides (NT-proBNP, BNP) in monitoring different types of cardiovascular disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases).
Methods: The NT-proBNP assay (Roche) was performed on 280 patients (mean age 49 years; range 20-89 years) and 48 healthy controls (mean age 43 years; range 13-65 years) and BNP assay (Bayer Shionoria) was performed in a subgroup of 42 patients (mean age 50 years; range 20-79 years). Patients were divided into four groups characterized by severity of heart failure according to the New York Heart Association classification.
Results: NT-proBNP concentrations differed in patients with cardiovascular diseases from controls (median 371 ng/l versus 41.5 ng/l, p < 0.0001). The cut off value of NT-proBNP determined in 280 patients with cardiovascular diseases was at 130 ng/l (AUC-area under curve = 0.93; sensitivity 98 %; specificity 79 %). Comparison of NT-proBNP and BNP values in patients showed significant correlation (r = 0.93; p < 0.0001). NT-proBNP showed significant differences between groups.
Conclusions: Measurement of brain natriuretic peptides is useful and relevant in various types of heart diseases including congenital.