PT  - JOURNAL ARTICLE
AU  - Kotaska, Karel
AU  - Popelova, Jana
AU  - Tiserova, Marie
AU  - Telekes, Peter
AU  - Vrzanova, Marie
AU  - Bronsky, Jiri
AU  - Halacova, Milada
AU  - Kukacka, Jiri
AU  - Prusa, Richard
TI  - THE RELEVANCE OF BRAIN NATRIURETIC PEPTIDES INVESTIGATION IN VARIOUS CARDIOVASCULAR DISEASES
DP  - 2006 Dec 1
TA  - Biomedical papers
PG  - 285--288
VI  - 150
IP  - 2
AID - 10.5507/bp.2006.043
IS  - 12138118
AB  - Background: Brain natriuretic peptides are relevant markers of heart impairment.
Aim: We investigated the relevance of investiging brain natriuretic peptides (NT-proBNP, BNP) in monitoring different types of cardiovascular disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases).
Methods: The NT-proBNP assay (Roche) was performed on 280 patients (mean age 49 years; range 20-89 years) and 48 healthy controls (mean age 43 years; range 13-65 years) and BNP assay (Bayer Shionoria) was performed in a subgroup of 42 patients (mean age 50 years; range 20-79 years). Patients were divided into four groups characterized by severity of heart failure according to the New York Heart Association classification.
Results: NT-proBNP concentrations differed in patients with cardiovascular diseases from controls (median 371 ng/l versus 41.5 ng/l, p < 0.0001). The cut off value of NT-proBNP determined in 280 patients with cardiovascular diseases was at 130 ng/l (AUC-area under curve = 0.93; sensitivity 98 %; specificity 79 %). Comparison of NT-proBNP and BNP values in patients showed significant correlation (r = 0.93; p < 0.0001). NT-proBNP showed significant differences between groups.
Conclusions: Measurement of brain natriuretic peptides is useful and relevant in various types of heart diseases including congenital.