RT Journal Article
SR Electronic
A1 Solichova, Pavlina
A1 Stejskal, David
A1 Proskova, Jitka
T1 Guanylins - Agents with natriuretic effect
JF Biomedical papers
YR 2006
VO 150
IS 1
SP 85
OP 87
DO 10.5507/bp.2006.010
UL https://biomed.papers.upol.cz/artkey/bio-200601-0011.php
AB Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl<sup>-</sup> secretion. A diet high in salt lead especially to increased guanylin and uroguanylin secretion. Interesting applications with guanylins measurement could to be in hypertension diagnosis, monitoring of heart dysfunction treatment, intensive care etc.