PT  - JOURNAL ARTICLE
AU  - Solichova, Pavlina
AU  - Stejskal, David
AU  - Proskova, Jitka
TI  - Guanylins - Agents with natriuretic effect
DP  - 2006 Jul 1
TA  - Biomedical papers
PG  - 85--87
VI  - 150
IP  - 1
AID - 10.5507/bp.2006.010
IS  - 12138118
AB  - Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl<sup>-</sup> secretion. A diet high in salt lead especially to increased guanylin and uroguanylin secretion. Interesting applications with guanylins measurement could to be in hypertension diagnosis, monitoring of heart dysfunction treatment, intensive care etc.