PT Journal
AU Solichova, P
   Stejskal, D
   Proskova, J
TI Guanylins - Agents with natriuretic effect
SO Biomedical papers
PY 2006
BP 85
EP 87
VL 150
IS 1
DI 10.5507/bp.2006.010
DE cGMP/G-C family/Guanylins/Proguanylin/Uroguanylin
AB Guanylins and uroguanylins are natriuretic peptides with different effects in many of tissues. In context with guanylins, the intestine-renal axis is presented. The overproduction of guanylin or uroguanylin leads to secondary diarrhea with stimulation of Cl<sup>-</sup> secretion. A diet high in salt lead especially to increased guanylin and uroguanylin secretion. Interesting applications with guanylins measurement could to be in hypertension diagnosis, monitoring of heart dysfunction treatment, intensive care etc.
ER