RT Journal Article
SR Electronic
A1 Letašiová, Silvia
A1 Jantová, Soňa
A1 Múčková, Marta
A1 Theiszová, Marica
T1 ANTIPROLIFERATIVE ACTIVITY OF BERBERINE IN VITRO AND IN VIVO
JF Biomedical papers
YR 2005
VO 149
IS 2
SP 461
OP 463
DO 10.5507/bp.2005.080
UL https://biomed.papers.upol.cz/artkey/bio-200502-0056.php
AB Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.