PT Journal
AU Letasiova, S
   Jantova, S
   Muckova, M
   Theiszova, M
TI ANTIPROLIFERATIVE ACTIVITY OF BERBERINE IN VITRO AND IN VIVO
SO Biomedical papers
PY 2005
BP 461
EP 463
VL 149
IS 2
DI 10.5507/bp.2005.080
DE Berberine/B16 cells/C57BL/6 mice/Antiproliferative activity
AB Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.
ER