RT Journal Article
SR Electronic
A1 Birošová, Lucia
A1 Mikulášová, Mária
T1 DEVELOPMENT OF CIPROFLOXACIN RESISTANCE DUE TO CHROMOSOMAL MUTATIONS INDUCED BY 2-NITROFLUORENE
JF Biomedical papers
YR 2005
VO 149
IS 2
SP 401
OP 403
DO 10.5507/bp.2005.068
UL https://biomed.papers.upol.cz/artkey/bio-200502-0044.php
AB In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.