PT  - JOURNAL ARTICLE
AU  - Birošová, Lucia
AU  - Mikulášová, Mária
TI  - DEVELOPMENT OF CIPROFLOXACIN RESISTANCE DUE TO CHROMOSOMAL MUTATIONS INDUCED BY 2-NITROFLUORENE
DP  - 2005 Dec 1
TA  - Biomedical papers
PG  - 401--403
VI  - 149
IP  - 2
AID - 10.5507/bp.2005.068
IS  - 12138118
AB  - In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.