PT Journal
AU Birosova, L
   Mikulasova, M
TI DEVELOPMENT OF CIPROFLOXACIN RESISTANCE DUE TO CHROMOSOMAL MUTATIONS INDUCED BY 2-NITROFLUORENE
SO Biomedical papers
PY 2005
BP 401
EP 403
VL 149
IS 2
DI 10.5507/bp.2005.068
DE 2-Nitrofluorene/Antibiotic resistance/Ciprofloxacin/Salmonella typhimurium
AB In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.
ER