RT Journal Article
SR Electronic
A1 Tulinska, Jana
A1 Kuricova, Miroslava
A1 Liskova, Aurelia
A1 Kovacikova, Zuzana
A1 Tatrai, Elizabeth
T1 THE EFFECT OF CERAMIC FIBERS ON THE IMMUNE SYSTEM
JF Biomedical papers
YR 2005
VO 149
IS 2
SP 397
OP 399
DO 10.5507/bp.2005.067
UL https://biomed.papers.upol.cz/artkey/bio-200502-0043.php
AB Male Sprague-Dawley rats were treated by intratracheal instillation with 1 mg/animal of refractory ceramic fibers. Intratracheal exposure to ceramic fibers led to significant changes of immune response. Results of proliferative activity of spleen lymphocytes showed significantly decreased proliferative activity of T-cells in response to mitogens phytohemagglutinin and concanavalin A in animals given ceramic fibers in comparison with control rats. Similarly, T-dependent B-cell response to pokeweed mitogen was significantly suppressed. Spontaneous proliferative activity of lymphocytes in non-stimulated spleen cell cultures did not differ in exposed and control rats. No significant changes were found among groups in percentage of phagocytic blood polymorphonuclear leukocytes and percentage of cells with respiratory burst.