PT  - JOURNAL ARTICLE
AU  - Kováčiková, Zuzana
AU  - Hurbánková, Marta
AU  - Tátrai, Erzsébet
AU  - Černá, Silvia
TI  - EFFECT OF INTRATRACHEAL FIBRES EXPOSURE ON THE RAT LUNG
DP  - 2005 Dec 1
TA  - Biomedical papers
PG  - 363--365
VI  - 149
IP  - 2
AID - 10.5507/bp.2005.059
IS  - 12138118
AB  - The changes in antioxidant status of rat lung after intratracheal instillation of stone-wool and glass fibres were studied. The animals were exposed to 2 or 8 mg of fibres for 4 or 16 weeks, the bronchoalveolar lavage was performed and the activity of superoxide dismutase, glutathione peroxidase and the total amount of glutathione was estimated both in tissue and in cell free fraction of bronchoalveolar lavage and the ascorbic acid was determined in lung tissue. The results showed the higher burden by stone-wool. Most changes were detected in groups exposed to higher dose of fibres for shorter time period, the most sensitive parameter was superoxide dismutase. The lung tissue was studied also by light microscopy and transmission electron microscopy.