RT Journal Article
SR Electronic
A1 Bartošová, Ladislava
A1 Novák, Filip
A1 Frydrych, Marek
A1 Parák, Tomáš
A1 Opatřilová, Radka
A1 Brunclík, Vít
A1 Kolevská, Jana
A1 El Moataz, Elnaggar
A1 Nečas, Jiří
T1 EFFECT OF A NEW ULTRASHORT BETALYTIC AGENT ON ACONITINE-INDUCED ARRHYTHMIA
JF Biomedical papers
YR 2005
VO 149
IS 2
SP 339
OP 343
DO 10.5507/bp.2005.054
UL https://biomed.papers.upol.cz/artkey/bio-200502-0030.php
AB The anti-arrhythmic effect was tested on the model of aconitine-induced arrhythmia. The experiment was performed in vivo with 31 male Wistar laboratory rats. Group A was first administered aconitine and, after the onset of the first sinus rhythm disorders, the 44Bu compound was administered. Group B was first administered the 44Bu compound and only after that the aconitine. The control group was administered aconitine and saline as a replacement of the tested compound. In group A, there was a decrease in the ventricular fibrillation occurrence from 100 % to 8 % (p < 0.001) after the administration of the 44Bu compound. In the B group, the onsets of all monitored arrhythmia types were delayed by an average of 15.6 min. Ventricular rhythm occurrence was decreased from 100 to 20 %, as well as ventricular fibrillations, from 100 to 0 % (p < 0.001).