PT  - JOURNAL ARTICLE
AU  - Bartošová, Ladislava
AU  - Novák, Filip
AU  - Frydrych, Marek
AU  - Parák, Tomáš
AU  - Opatřilová, Radka
AU  - Brunclík, Vít
AU  - Kolevská, Jana
AU  - El Moataz, Elnaggar
AU  - Nečas, Jiří
TI  - EFFECT OF A NEW ULTRASHORT BETALYTIC AGENT ON ACONITINE-INDUCED ARRHYTHMIA
DP  - 2005 Dec 1
TA  - Biomedical papers
PG  - 339--343
VI  - 149
IP  - 2
AID - 10.5507/bp.2005.054
IS  - 12138118
AB  - The anti-arrhythmic effect was tested on the model of aconitine-induced arrhythmia. The experiment was performed in vivo with 31 male Wistar laboratory rats. Group A was first administered aconitine and, after the onset of the first sinus rhythm disorders, the 44Bu compound was administered. Group B was first administered the 44Bu compound and only after that the aconitine. The control group was administered aconitine and saline as a replacement of the tested compound. In group A, there was a decrease in the ventricular fibrillation occurrence from 100 % to 8 % (p < 0.001) after the administration of the 44Bu compound. In the B group, the onsets of all monitored arrhythmia types were delayed by an average of 15.6 min. Ventricular rhythm occurrence was decreased from 100 to 20 %, as well as ventricular fibrillations, from 100 to 0 % (p < 0.001).