RT Journal Article
SR Electronic
A1 Jirsová, Zuzana
A1 Kučera, Tomáš
A1 Martínek, Jindřich
A1 Liška, František
A1 Křenová, Drahomíra
A1 Křen, Vladimír
T1 ALTERED SPERMATOGENESIS IN THE HYPODACTYLOUS RATS
JF Biomedical papers
YR 2004
VO 148
IS 2
SP 213
OP 215
DO 10.5507/bp.2004.042
UL https://biomed.papers.upol.cz/artkey/bio-200402-0023.php
AB Germinal epithelium of seminiferous tubules in adult, infertile hypodactylous males displays significant reduction in the number of germ-line cells. Detection of apoptosis in the germ-line cells during postnatal differentiation was performed to elucidate the mechanism of the decreased number of germ cells in the testes of adult rats. Evaluation of DNA fragmentation and expression of activated caspase-3 in germ cells did not confirm marked germ cell death during the onset of spermatogenesis as a main cause of significant reduction of germ cells in Hd/Hd testes of adult males. The primary cause of spermatogenesis deffect seems to be rather associated with a disorder in the cell cycle regulation and interrelation of germ-line cells with Sertoli cells.